Literature DB >> 1325436

UCT4B, a new antitumor antibiotic with topoisomerase II mediated DNA cleavage activity, from Streptomyces sp.

S Z Kawada1, Y Yamashita, Y Uosaki, K Gomi, T Iwasaki, T Takiguchi, H Nakano.   

Abstract

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Year:  1992        PMID: 1325436     DOI: 10.7164/antibiotics.45.1182

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


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  6 in total

1.  Clerocidin alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action.

Authors:  Sara Richter; Barbara Gatto; Daniele Fabris; Ken-ichi Takao; Susumu Kobayashi; Manlio Palumbo
Journal:  Nucleic Acids Res       Date:  2003-09-01       Impact factor: 16.971

2.  Concerted bis-alkylating reactivity of clerocidin towards unpaired cytosine residues in DNA.

Authors:  Sara N Richter; Ileana Menegazzo; Daniele Fabris; Manlio Palumbo
Journal:  Nucleic Acids Res       Date:  2004-10-19       Impact factor: 16.971

3.  The topoisomerase II poison clerocidin alkylates non-paired guanines of DNA: implications for irreversible stimulation of DNA cleavage.

Authors:  B Gatto; S Richter; S Moro; G Capranico; M Palumbo
Journal:  Nucleic Acids Res       Date:  2001-10-15       Impact factor: 16.971

Review 4.  Bacterial terpenome.

Authors:  Jeffrey D Rudolf; Tyler A Alsup; Baofu Xu; Zining Li
Journal:  Nat Prod Rep       Date:  2021-05-26       Impact factor: 15.111

Review 5.  Building trans-bicyclo[4.4.0]decanes/decenes in complex multifunctional frameworks: the case for antibiotic development.

Authors:  Wanli Zhang; Anna R Kaplan; Emma K Davison; Jared L Freeman; Margaret A Brimble; William M Wuest
Journal:  Nat Prod Rep       Date:  2021-05-26       Impact factor: 13.423

6.  Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage.

Authors:  Xiao Su Pan; Miriam Dias; Manlio Palumbo; L Mark Fisher
Journal:  Nucleic Acids Res       Date:  2008-08-22       Impact factor: 16.971

  6 in total

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