Literature DB >> 1323957

Lack of effect of carbonyl cyanide m-chlorophenylhydrazone on KB-5246 accumulation by Staphylococcus aureus.

Y Kotera1, Y Inoue, M Ohashi, K Ito, M Inoue.   

Abstract

The accumulation of KB-5246 in a quinolone-susceptible strain of Staphylococcus aureus was about 70 times that of norfloxacin. Carbonyl cyanide m-chlorophenylhydrazone increased the accumulation of norfloxacin about eightfold, but it did not influence that of KB-5246. The low efflux of KB-5246 from S. aureus may contribute to its potent antibacterial activity.

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Year:  1992        PMID： 1323957      PMCID： PMC189480          DOI： 10.1128/AAC.36.4.883

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

1.  Accumulation of enoxacin by Escherichia coli and Bacillus subtilis.

Authors:  J Bedard; S Wong; L E Bryan
Journal:  Antimicrob Agents Chemother       Date:  1987-09       Impact factor: 5.191

2.  Differences in susceptibility to quinolones of outer membrane mutants of Salmonella typhimurium and Escherichia coli.

Authors:  K Hirai; H Aoyama; T Irikura; S Iyobe; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1986-03       Impact factor: 5.191

3.  Comparative antibacterial activity of new quinolone-carboxylic acid derivatives.

Authors:  S Mitsuhashi
Journal:  Rev Infect Dis       Date:  1988 Jan-Feb

4.  In vitro and in vivo antibacterial activities of KB-5246, a new tetracyclic quinolone.

Authors:  Y Kotera; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1989-11       Impact factor: 5.191

5.  Endogenous active efflux of norfloxacin in susceptible Escherichia coli.

Authors:  S P Cohen; D C Hooper; J S Wolfson; K S Souza; L M McMurry; S B Levy
Journal:  Antimicrob Agents Chemother       Date:  1988-08       Impact factor: 5.191

6.  Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones.

Authors:  H Yoshida; M Bogaki; S Nakamura; K Ubukata; M Konno
Journal:  J Bacteriol       Date:  1990-12       Impact factor: 3.490

7.  Activity of KB-5246 against outer membrane mutants of Escherichia coli and Salmonella typhimurium.

Authors:  Y Kotera; M Inoue; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1990-07       Impact factor: 5.191

8.  Uptake of sparfloxacin and norfloxacin by clinical isolates of Staphylococcus aureus.

Authors:  S Yoshida; T Kojima; M Inoue; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1991-02       Impact factor: 5.191

9.  Contribution of permeability and sensitivity to inhibition of DNA synthesis in determining susceptibilities of Escherichia coli, Pseudomonas aeruginosa, and Alcaligenes faecalis to ciprofloxacin.

Authors:  J Bedard; S Chamberland; S Wong; T Schollaardt; L E Bryan
Journal:  Antimicrob Agents Chemother       Date:  1989-09       Impact factor: 5.191

10.  Isolation and characterization of norfloxacin-resistant mutants of Escherichia coli K-12.

Authors:  K Hirai; H Aoyama; S Suzue; T Irikura; S Iyobe; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1986-08       Impact factor: 5.191
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