Literature DB >> 3521490

Differences in susceptibility to quinolones of outer membrane mutants of Salmonella typhimurium and Escherichia coli.

K Hirai, H Aoyama, T Irikura, S Iyobe, S Mitsuhashi.   

Abstract

The mechanism of penetration of quinolones through the bacterial outer membrane was studied with lipopolysaccharide-deficient and porin-deficient mutants. The data indicated that the lipopolysaccharide layer might form a permeability barrier for hydrophobic quinolones such as nalidixic acid but not for hydrophilic quinolones such as norfloxacin and ciprofloxacin. The results also showed that quinolones with a low relative hydrophobicity appeared to permeate through OmpF porin, whereas quinolones with a low relative hydrophobicity appeared to permeate through OmpF porin, whereas quinolones with a high relative hydrophobicity appeared to permeate through both OmpF porin and phospholipid bilayers.

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Year:  1986        PMID： 3521490      PMCID： PMC180431          DOI： 10.1128/AAC.29.3.535

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

Review 1.  The role of the bacterial cell envelope in antibiotic resistance.

Authors:  J W Costerton; K J Cheng
Journal:  J Antimicrob Chemother       Date:  1975-12       Impact factor: 5.790

2.  The effect of defined lipopolysaccharide core defects upon antibiotic resistances of Salmonella typhimurium.

Authors:  R J Roantree; T T Kuo; D G MacPhee
Journal:  J Gen Microbiol       Date:  1977-12

Review 3.  The outer membrane of Gram-negative bacteria.

Authors:  H Nikaido; T Nakae
Journal:  Adv Microb Physiol       Date:  1979       Impact factor: 3.517

4.  Studies on the mechanism of action of nalidixic acid.

Authors:  G J Bourguignon; M Levitt; R Sternglanz
Journal:  Antimicrob Agents Chemother       Date:  1973-10       Impact factor: 5.191

Review 5.  The barrier function of the gram-negative envelope.

Authors:  L Leive
Journal:  Ann N Y Acad Sci       Date:  1974-05-10       Impact factor: 5.691

6.  Outer membrane of Salmonella typhimurium. Transmembrane diffusion of some hydrophobic substances.

Authors:  H Nikaido
Journal:  Biochim Biophys Acta       Date:  1976-04-16

7.  The bacterial outer-membrane permeability of beta-lactam antibiotics.

Authors:  T Sawai; K Matsuba; A Tamura; S Yamagishi
Journal:  J Antibiot (Tokyo)       Date:  1979-01       Impact factor: 2.649

8.  Function of the outer membrane of Escherichia coli as a permeability barrier to beta-lactam antibiotics.

Authors:  W Zimmermann; A Rosselet
Journal:  Antimicrob Agents Chemother       Date:  1977-09       Impact factor: 5.191

9.  In vitro antibacterial activity of AM-715, a new nalidixic acid analog.

Authors:  A Ito; K Hirai; M Inoue; H Koga; S Suzue; T Irikura; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1980-02       Impact factor: 5.191

10.  Mode of action of a new nalidixic acid derivative, AB206.

Authors:  T Nagate; T Komatsu; A Izawa; S Ohmura; S Namiki; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1980-05       Impact factor: 5.191
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  102 in total

1.  Antagonism of wild-type and resistant Escherichia coli and its DNA gyrase by the tricyclic 4-quinolone analogs ofloxacin and S-25930 stereoisomers.

Authors:  J S Wolfson; D C Hooper; E Y Ng; K S Souza; G L McHugh; M N Swartz
Journal:  Antimicrob Agents Chemother       Date:  1987-11       Impact factor: 5.191

2.  Norfloxacin resistance in a clinical isolate of Escherichia coli.

Authors:  H Aoyama; K Sato; T Kato; K Hirai; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1987-10       Impact factor: 5.191

3.  Mechanisms of quinolone resistance in a clinical isolate of Escherichia coli highly resistant to fluoroquinolones but susceptible to nalidixic acid.

Authors:  N Moniot-Ville; J Guibert; N Moreau; J F Acar; E Collatz; L Gutmann
Journal:  Antimicrob Agents Chemother       Date:  1991-03       Impact factor: 5.191

4.  Cloning and expression of the norA gene for fluoroquinolone resistance in Staphylococcus aureus.

Authors:  K Ubukata; N Itoh-Yamashita; M Konno
Journal:  Antimicrob Agents Chemother       Date:  1989-09       Impact factor: 5.191

5.  Mutation of Salmonella paratyphi A conferring cross-resistance to several groups of antibiotics by decreased permeability and loss of invasiveness.

Authors:  L Gutmann; D Billot-Klein; R Williamson; F W Goldstein; J Mounier; J F Acar; E Collatz
Journal:  Antimicrob Agents Chemother       Date:  1988-02       Impact factor: 5.191

Review 6.  The mode of action of quinolones: the paradox in activity of low and high concentrations and activity in the anaerobic environment.

Authors:  C S Lewin; I Morrissey; J T Smith
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1991-04       Impact factor: 3.267

7.  In vitro activity of amifloxacin against outer membrane mutants of the family Enterobacteriaceae and frequency of spontaneous resistance.

Authors:  M Watanabe; M Inoue; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1989-11       Impact factor: 5.191

8.  Contribution of permeability and sensitivity to inhibition of DNA synthesis in determining susceptibilities of Escherichia coli, Pseudomonas aeruginosa, and Alcaligenes faecalis to ciprofloxacin.

Authors:  J Bedard; S Chamberland; S Wong; T Schollaardt; L E Bryan
Journal:  Antimicrob Agents Chemother       Date:  1989-09       Impact factor: 5.191

9.  Factors influencing the accumulation of ciprofloxacin in Pseudomonas aeruginosa.

Authors:  R A Celesk; N J Robillard
Journal:  Antimicrob Agents Chemother       Date:  1989-11       Impact factor: 5.191

10.  Fluorescence quenching as a tool to investigate quinolone antibiotic interactions with bacterial protein OmpF.

Authors:  Patrícia Neves; Isabel Sousa; Mathias Winterhalter; Paula Gameiro
Journal:  J Membr Biol       Date:  2009-01-16       Impact factor: 1.843
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