Literature DB >> 1322935

Psoralen preparation of antigenically intact noninfectious rotavirus particles.

W S Groene1, R D Shaw.   

Abstract

The use of the synthetic psoralen 4'-aminomethyl-4,5',8-trimethylpsoralen hydrochloride (AMT) is described for the inactivation of infectious rotavirus, a member of the viral family Reoviradae with a double-stranded RNA genome. This method not only provides complete inactivation of the virus but leaves antigenically intact particles. The lack of viral replication following inactivation was determined with an immunohistochemical focus assay. The antigenic authenticity of the particles was determined by monoclonal antibody ELISA and a viral hemagglutination assay.

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Year:  1992        PMID： 1322935     DOI： 10.1016/0166-0934(92)90172-a

Source DB:  PubMed          Journal:  J Virol Methods        ISSN： 0166-0934            Impact factor:   2.014


  34 in total

1.  Rotavirus infection induces the unfolded protein response of the cell and controls it through the nonstructural protein NSP3.

Authors:  Vicenta Trujillo-Alonso; Liliana Maruri-Avidal; Carlos F Arias; Susana López
Journal:  J Virol       Date:  2011-09-21       Impact factor: 5.103

2.  Immunologic correlates of protection against rotavirus challenge after intramuscular immunization of mice.

Authors:  S E Coffin; C A Moser; S Cohen; H F Clark; P A Offit
Journal:  J Virol       Date:  1997-10       Impact factor: 5.103

3.  Rotavirus replication in intestinal cells differentially regulates integrin expression by a phosphatidylinositol 3-kinase-dependent pathway, resulting in increased cell adhesion and virus yield.

Authors:  Peter Halasz; Gavan Holloway; Stephen J Turner; Barbara S Coulson
Journal:  J Virol       Date:  2007-10-17       Impact factor: 5.103

4.  A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection.

Authors:  Kapil Saxena; Lukas M Simon; Xi-Lei Zeng; Sarah E Blutt; Sue E Crawford; Narayan P Sastri; Umesh C Karandikar; Nadim J Ajami; Nicholas C Zachos; Olga Kovbasnjuk; Mark Donowitz; Margaret E Conner; Chad A Shaw; Mary K Estes
Journal:  Proc Natl Acad Sci U S A       Date:  2017-01-09       Impact factor: 11.205

5.  Osteopontin upregulation in rotavirus-induced murine biliary atresia requires replicating virus but is not necessary for development of biliary atresia.

Authors:  Paula M Hertel; Sue E Crawford; Milton J Finegold; Mary K Estes
Journal:  Virology       Date:  2011-07-13       Impact factor: 3.616

6.  Rotavirus acceleration of murine type 1 diabetes is associated with a T helper 1-dependent specific serum antibody response and virus effects in regional lymph nodes.

Authors:  J A Pane; N L Webster; K L Graham; G Holloway; C Zufferey; B S Coulson
Journal:  Diabetologia       Date:  2012-12-14       Impact factor: 10.122

7.  Immunogenicity of a psoralen-inactivated dengue virus type 1 vaccine candidate in mice.

Authors:  Ryan C Maves; Roger M Castillo Oré; Kevin R Porter; Tadeusz J Kochel
Journal:  Clin Vaccine Immunol       Date:  2009-12-09

8.  Rotavirus structural proteins and dsRNA are required for the human primary plasmacytoid dendritic cell IFNalpha response.

Authors:  Emily M Deal; Maria C Jaimes; Sue E Crawford; Mary K Estes; Harry B Greenberg
Journal:  PLoS Pathog       Date:  2010-06-03       Impact factor: 6.823

9.  Intestinal epithelia activate anti-viral signaling via intracellular sensing of rotavirus structural components.

Authors:  A H Frias; M Vijay-Kumar; J R Gentsch; S E Crawford; F A Carvalho; M K Estes; A T Gewirtz
Journal:  Mucosal Immunol       Date:  2010-07-21       Impact factor: 7.313

10.  Induction of interleukin-6 after stimulation of human B-cell CD21 by Epstein-Barr virus glycoproteins gp350 and gp220.

Authors:  J E Tanner; C Alfieri; T A Chatila; F Diaz-Mitoma
Journal:  J Virol       Date:  1996-01       Impact factor: 5.103
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