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Literature DB >> 1322122

Inhibitory effect of zinc on stimulated erythropoietin synthesis in HepG2 cells.

Abstract

The effect of zinc on erythropoietin (EPO) synthesis in HepG2 cells was investigated. The increase in EPO synthesis induced by Co2+ (50 microM), Ni2+ (300 microM) or oxygen (1% O2) was inhibited by the presence of ZnCl2 (50-150 microM) in the tissue-culture medium, whereas basal EPO synthesis was unaffected. The effect was reflected by corresponding changes in the EPO mRNA level. These effects of zinc on EPO synthesis could not be mimicked by CdCl2 (less than or equal to 2 microM). Addition of FeCl3 to the medium appeared to decrease the inhibitory effect of zinc on hypoxia-induced EPO synthesis, implying that zinc may interfere with an iron-dependent step in EPO regulation.

Entities: Chemical Disease Gene

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Year: 1992 PMID： 1322122 PMCID： PMC1132752 DOI： 10.1042/bj2850113

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

30 in total

1. Transactivation of the P2 promoter of parathyroid hormone-related protein by human T-cell lymphotropic virus type I Tax1: evidence for the involvement of transcription factor Ets1.

Authors: J Dittmer; S D Gitlin; R L Reid; J N Brady
Journal: J Virol Date: 1993-10 Impact factor: 5.103

1 in total

Inhibitory effect of zinc on stimulated erythropoietin synthesis in HepG2 cells.

1. Characterization of a transferrin-independent uptake system for iron in HeLa cells.

2. delta-Aminolaevulinate synthase in human HepG2 hepatoma cells. Repression by haemin and induction by chemicals.

3. Structure and expression of the human metallothionein genes.

4. Evidence suggesting negative regulation of the erythropoietin gene by ribonucleoprotein.

5. Enhancement by hypoxia of human erythropoietin gene transcription in vitro.

6. The liver cell plasma membrane Ca2+ inflow systems exhibit a broad specificity for divalent metal ions.

7. Enhanced erythropoietin secretion in hepatoblastoma cells in response to hypoxia.

8. Derepression of ferritin messenger RNA translation by hemin in vitro.

9. Inhibition of haem synthesis caused by cobalt in rat liver. Evidence for two different sites of action.

10. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

1. Transactivation of the P2 promoter of parathyroid hormone-related protein by human T-cell lymphotropic virus type I Tax1: evidence for the involvement of transcription factor Ets1.