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Literature DB >> 1321292

Epstein-Barr virus-encoded small RNAs (EBERs) do not modulate interferon effects in infected lymphocytes.

S Swaminathan¹, B S Huneycutt, C S Reiss, E Kieff.

Abstract

The recent derivation of otherwise isogenic Epstein-Barr virus (EBV) recombinants carrying or lacking the EBV small RNA (EBER) genes enabled us to test whether EBERs are similar to adenovirus VA RNAs in modulating interferon (IFN) effects on virus infection. EBER-positive and -negative EBV recombinants did not differ in their sensitivity to alpha interferon (IFN-alpha)- or IFN-gamma-mediated inhibition of lymphocyte growth transformation. In addition, EBERs did not decrease the inhibitory effects of IFN on vesicular stomatitis virus replication in EBV-transformed lymphocytes. EBER deletion also did not render EBV-transformed B lymphocytes susceptible to an IFN effect on cell proliferation or EBV replication.

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Year: 1992 PMID： 1321292 PMCID： PMC241388

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

20 in total

1. Epstein-Barr virus nuclear protein 2 is a key determinant of lymphocyte transformation.

Authors: J I Cohen; F Wang; J Mannick; E Kieff
Journal: Proc Natl Acad Sci U S A Date: 1989-12 Impact factor: 11.205

2. Binding of Epstein-Barr virus small RNA EBER-1 to the double-stranded RNA-activated protein kinase DAI.

Authors: P A Clarke; M Schwemmle; J Schickinger; K Hilse; M J Clemens
Journal: Nucleic Acids Res Date: 1991-01-25 Impact factor: 16.971

3. Recombinant Epstein-Barr virus with small RNA (EBER) genes deleted transforms lymphocytes and replicates in vitro.

Authors: S Swaminathan; B Tomkinson; E Kieff
Journal: Proc Natl Acad Sci U S A Date: 1991-02-15 Impact factor: 11.205

4. Translational control by the Epstein-Barr virus small RNA EBER-1. Reversal of the double-stranded RNA-induced inhibition of protein synthesis in reticulocyte lysates.

Authors: P A Clarke; N A Sharp; M J Clemens
Journal: Eur J Biochem Date: 1990-11-13

5. A second Epstein-Barr virus membrane protein (LMP2) is expressed in latent infection and colocalizes with LMP1.

Authors: R Longnecker; E Kieff
Journal: J Virol Date: 1990-05 Impact factor: 5.103

6. Striking similarities are exhibited by two small Epstein-Barr virus-encoded ribonucleic acids and the adenovirus-associated ribonucleic acids VAI and VAII.

Authors: M D Rosa; E Gottlieb; M R Lerner; J A Steitz
Journal: Mol Cell Biol Date: 1981-09 Impact factor: 4.272

7. Two families of sequences in the small RNA-encoding region of Epstein-Barr virus (EBV) correlate with EBV types A and B.

Authors: J R Arrand; L S Young; J D Tugwood
Journal: J Virol Date: 1989-02 Impact factor: 5.103

8. Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2 alpha kinase.

Authors: J Kitajewski; R J Schneider; B Safer; S M Munemitsu; C E Samuel; B Thimmappaya; T Shenk
Journal: Cell Date: 1986-04-25 Impact factor: 41.582

9. Regulation of Epstein-Barr virus infection by recombinant interferons. Selected sensitivity to interferon-gamma.

Authors: M Lotz; C D Tsoukas; S Fong; D A Carson; J H Vaughan
Journal: Eur J Immunol Date: 1985-05 Impact factor: 5.532

10. Influence of Burkitt's lymphoma and primary B cells on latent gene expression by the nonimmortalizing P3J-HR-1 strain of Epstein-Barr virus.

Authors: C Rooney; J G Howe; S H Speck; G Miller
Journal: J Virol Date: 1989-04 Impact factor: 5.103

22 in total

1. Epstein-Barr virus small RNAs potentiate tumorigenicity of Burkitt lymphoma cells independently of an effect on apoptosis.

Authors: I K Ruf; P W Rhyne; C Yang; J L Cleveland; J T Sample
Journal: J Virol Date: 2000-11 Impact factor: 5.103

Review 2. Noncoding RNPs of viral origin.

Authors: Joan Steitz; Sumit Borah; Demian Cazalla; Victor Fok; Robin Lytle; Rachel Mitton-Fry; Kasandra Riley; Tasleem Samji
Journal: Cold Spring Harb Perspect Biol Date: 2011-03-01 Impact factor: 10.005

3. Critical role of Epstein-Barr Virus (EBV)-encoded RNA in efficient EBV-induced B-lymphocyte growth transformation.

Authors: Misako Yajima; Teru Kanda; Kenzo Takada
Journal: J Virol Date: 2005-04 Impact factor: 5.103

4. The Epstein-Barr virus-encoded LMP-1 oncoprotein negatively affects Tyk2 phosphorylation and interferon signaling in human B cells.

Authors: Timothy R Geiger; Jennifer M Martin
Journal: J Virol Date: 2006-09-20 Impact factor: 5.103

8. In vitro selection of RNA ligands for the ribosomal L22 protein associated with Epstein-Barr virus-expressed RNA by using randomized and cDNA-derived RNA libraries.

Authors: M Dobbelstein; T Shenk
Journal: J Virol Date: 1995-12 Impact factor: 5.103

Review 9. The small RNAs of Epstein-Barr virus.

Authors: M J Clemens
Journal: Mol Biol Rep Date: 1993-02 Impact factor: 2.316

10. Functional interaction and colocalization of the herpes simplex virus 1 major regulatory protein ICP4 with EAP, a nucleolar-ribosomal protein.

Authors: R Leopardi; B Roizman
Journal: Proc Natl Acad Sci U S A Date: 1996-05-14 Impact factor: 11.205