Literature DB >> 1318216

Gamma-hydroxybutyrate hyperpolarizes hippocampal neurones by activating GABAB receptors.

X Xie1, T G Smart.   

Abstract

gamma-Hydroxybutyrate, a naturally occurring substance present in the mammalian central nervous system caused a dose-dependent (0.25-10 mM) hyperpolarization and small membrane conductance increase when applied to hippocampal CA1 pyramidal neurones in vitro. This action was reversibly inhibited by the GABAB antagonist, CGP 35348 (20-100 microM) and divalent cations, Zn2+ and Ba2+, but not by the GABAA antagonist bicuculline (50 microM). These results suggest that GABAB receptors may mediate the actions of gamma-hydroxybutyrate.

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Year:  1992        PMID： 1318216     DOI： 10.1016/0014-2999(92)90347-7

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  13 in total

1.  GABA(B) receptor-mediated modulation of hypocretin/orexin neurones in mouse hypothalamus.

Authors:  Xinmin Xie; Tara L Crowder; Akihiro Yamanaka; Stephen R Morairty; Robin D Lewinter; Takeshi Sakurai; Thomas S Kilduff
Journal:  J Physiol       Date:  2006-04-20       Impact factor: 5.182

2.  The GABAB-receptor antagonist, CGP 35348, antagonises gamma-hydroxybutyrate- and baclofen-induced alterations in locomotor activity and forebrain dopamine levels in mice.

Authors:  H Nissbrandt; G Engberg
Journal:  J Neural Transm (Vienna)       Date:  1996       Impact factor: 3.575

3.  Extrasynaptic site of action for γ-hydroxybutyrate.

Authors:  S J Enna
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-31       Impact factor: 11.205

4.  gamma-aminobutyric acid type B receptors are expressed and functional in mammalian cardiomyocytes.

Authors:  P Lorente; A Lacampagne; Y Pouzeratte; S Richards; B Malitschek; R Kuhn; B Bettler; G Vassort
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-18       Impact factor: 11.205

Review 5.  gamma-Hydroxybutyrate/sodium oxybate: neurobiology, and impact on sleep and wakefulness.

Authors:  Daniel Pardi; Jed Black
Journal:  CNS Drugs       Date:  2006       Impact factor: 5.749

Review 6.  Challenges in the development of therapeutics for narcolepsy.

Authors:  Sarah Wurts Black; Akihiro Yamanaka; Thomas S Kilduff
Journal:  Prog Neurobiol       Date:  2015-12-23       Impact factor: 11.685

7.  Gammahydroxybutyrate (GHB) receptor ligand effects on evoked synaptic field potentials in CA1 of the rat hippocampal slice.

Authors:  M A King; J S Thinschmidt; D W Walker
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

8.  Neurophysiological signature of gamma-hydroxybutyrate augmented sleep in male healthy volunteers may reflect biomimetic sleep enhancement: a randomized controlled trial.

Authors:  Dario A Dornbierer; Diego M Baur; Benjamin Stucky; Boris B Quednow; Thomas Kraemer; Erich Seifritz; Oliver G Bosch; Hans-Peter Landolt
Journal:  Neuropsychopharmacology       Date:  2019-04-08       Impact factor: 7.853

9.  Pathway-specific action of gamma-hydroxybutyric acid in sensory thalamus and its relevance to absence seizures.

Authors:  Nicolas Gervasi; Zohreh Monnier; Pierre Vincent; Daniele Paupardin-Tritsch; Stuart W Hughes; Vincenzo Crunelli; Nathalie Leresche
Journal:  J Neurosci       Date:  2003-12-10       Impact factor: 6.167

Review 10.  Behavioral analyses of GHB: receptor mechanisms.

Authors:  Lawrence P Carter; Wouter Koek; Charles P France
Journal:  Pharmacol Ther       Date:  2008-10-29       Impact factor: 12.310
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