Literature DB >> 1317148

Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential.

K Suomalainen1, T Sorsa, L M Golub, N Ramamurthy, H M Lee, V J Uitto, H Saari, Y T Konttinen.   

Abstract

The concentrations of doxycycline and 4-de-dimethylaminotetracycline required to inhibit 50% of collagenase activity were found to be 15 to 30 microM for human neutrophil and gingival crevicular fluid collagenases. Fibroblast collagenase was relatively resistant to inhibition by tetracyclines; the 50% inhibitory concentrations of doxycycline and 4-de-dimethylaminotetracycline were 280 and 510 microM, respectively.

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Year:  1992        PMID： 1317148      PMCID： PMC189275          DOI： 10.1128/AAC.36.1.227

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

1.  A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization.

Authors:  Y Okada; H Nagase; E D Harris
Journal:  J Biol Chem       Date:  1986-10-25       Impact factor: 5.157

2.  Minocycline for dystrophic epidermolysis bullosa.

Authors:  J E White
Journal:  Lancet       Date:  1989-04-29       Impact factor: 79.321

3.  Minocycline treatment for rheumatoid arthritis: an open dose finding study.

Authors:  F C Breedveld; B A Dijkmans; H Mattie
Journal:  J Rheumatol       Date:  1990-01       Impact factor: 4.666

4.  Comparison of interstitial collagenases from human gingiva, sulcular fluid and polymorphonuclear leukocytes.

Authors:  T Sorsa; V J Uitto; K Suomalainen; M Vauhkonen; S Lindy
Journal:  J Periodontal Res       Date:  1988-11       Impact factor: 4.419

5.  Minocycline reduces gingival collagenolytic activity during diabetes. Preliminary observations and a proposed new mechanism of action.

Authors:  L M Golub; H M Lee; G Lehrer; A Nemiroff; T F McNamara; R Kaplan; N S Ramamurthy
Journal:  J Periodontal Res       Date:  1983-09       Impact factor: 4.419

6.  Human neutrophil collagenase cleaves alpha 1-antitrypsin.

Authors:  J Michaelis; M C Vissers; C C Winterbourn
Journal:  Biochem J       Date:  1990-09-15       Impact factor: 3.857

7.  Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases.

Authors:  K A Hasty; T F Pourmotabbed; G I Goldberg; J P Thompson; D G Spinella; R M Stevens; C L Mainardi
Journal:  J Biol Chem       Date:  1990-07-15       Impact factor: 5.157

8.  Salivary collagenase. Origin, characteristics and relationship to periodontal health.

Authors:  V J Uitto; K Suomalainen; T Sorsa
Journal:  J Periodontal Res       Date:  1990-05       Impact factor: 4.419

9.  Human alveolar macrophages produce a fibroblast-like collagenase and collagenase inhibitor.

Authors:  H G Welgus; E J Campbell; Z Bar-Shavit; R M Senior; S L Teitelbaum
Journal:  J Clin Invest       Date:  1985-07       Impact factor: 14.808

10.  Tetracycline: levels of achievable in gingival crevice fluid and in vitro effect on subgingival organisms. Part II. Susceptibilities of periodontal bacteria.

Authors:  C B Walker; J M Gordon; S J McQuilkin; T A Niebloom; S S Socransky
Journal:  J Periodontol       Date:  1981-10       Impact factor: 6.993
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  21 in total

Review 1.  Interference of antibacterial agents with phagocyte functions: immunomodulation or "immuno-fairy tales"?

Authors:  M T Labro
Journal:  Clin Microbiol Rev       Date:  2000-10       Impact factor: 26.132

2.  Doxycycline reduces mortality and injury to the brain and cochlea in experimental pneumococcal meningitis.

Authors:  Damian N Meli; Roney S Coimbra; Dominik G Erhart; Gerard Loquet; Caroline L Bellac; Martin G Täuber; Ulf Neumann; Stephen L Leib
Journal:  Infect Immun       Date:  2006-07       Impact factor: 3.441

3.  Targeted drug delivery to emphysematous lungs: Inhibition of MMPs by doxycycline loaded nanoparticles.

Authors:  Vaideesh Parasaram; Nasim Nosoudi; Renee J LeClair; Andrew Binks; Naren Vyavahare
Journal:  Pulm Pharmacol Ther       Date:  2016-06-25       Impact factor: 3.410

4.  Tear fluid levels of MMP-8 are elevated in ocular rosacea--treatment effect of oral doxycycline.

Authors:  Marko Määttä; Osmo Kari; Taina Tervahartiala; Sirje Peltonen; Marjatta Kari; Matti Saari; Timo Sorsa
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2006-01-13       Impact factor: 3.117

5.  Doxycycline inhibits polarization of macrophages to the proangiogenic M2-type and subsequent neovascularization.

Authors:  Lizhi He; Alexander G Marneros
Journal:  J Biol Chem       Date:  2014-02-06       Impact factor: 5.157

Review 6.  The immune response and antibacterial therapy.

Authors:  Olachi Anuforom; Graham R Wallace; Laura V Piddock
Journal:  Med Microbiol Immunol       Date:  2014-09-05       Impact factor: 3.402

7.  Peripheral ulcerative keratitis: Our challenging experience.

Authors:  Bandar Al-Qahtani; Salman Asghar; Hassan Mohammad Al-Taweel; Imran Jalaluddin
Journal:  Saudi J Ophthalmol       Date:  2013-12-21

8.  The tetracycline analogs minocycline and doxycycline inhibit angiogenesis in vitro by a non-metalloproteinase-dependent mechanism.

Authors:  S Gilbertson-Beadling; E A Powers; M Stamp-Cole; P S Scott; T L Wallace; J Copeland; G Petzold; M Mitchell; S Ledbetter; R Poorman
Journal:  Cancer Chemother Pharmacol       Date:  1995       Impact factor: 3.333

9.  Reduction of matrix metalloproteinase 8-neutrophil collagenase levels during long-term doxycycline treatment of reactive arthritis.

Authors:  A Lauhio; Y T Konttinen; H Tschesche; D Nordström; T Salo; J Lähdevirta; L M Golub; T Sorsa
Journal:  Antimicrob Agents Chemother       Date:  1994-02       Impact factor: 5.191

Review 10.  Chemotherapy of lepromatous leprosy: recent developments and prospects for the future.

Authors:  R H Gelber
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1994-11       Impact factor: 3.267
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