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Literature DB >> 1317145

In vitro and in vivo activities of sparfloxacin, other quinolones, and tetracyclines against Chlamydia trachomatis.

K Nakata¹, H Maeda, A Fujii, S Arakawa, K Umezu, S Kamidono.

Abstract

Sparfloxacin was more potent than other quinolones (tosufloxacin, lomefloxacin, ciprofloxacin, ofloxacin, fleroxacin, enoxacin, and norfloxacin) and as potent as minocycline and doxycycline in activity against Chlamydia trachomatis in vitro and in vivo. Sparfloxacin was more bactericidal than minocycline against C. trachomatis D/UW-3/Cx.

Entities: Chemical Species

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Year: 1992 PMID： 1317145 PMCID： PMC189251 DOI： 10.1128/AAC.36.1.188

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

11 in total

1. Renal handling of fleroxacin in rabbits, dogs, and humans.

Authors: K Shiba; A Saito; J Shimada; S Hori; M Kaji; T Miyahara; H Kusajima; S Kaneko; S Saito; T Ooie
Journal: Antimicrob Agents Chemother Date: 1990-01 Impact factor: 5.191

Review 2. Chlamydial infections (third of three parts).

Authors: J Schachter
Journal: N Engl J Med Date: 1978-03-09 Impact factor: 91.245

3. In-vitro activity of azithromycin, erythromycin, ciprofloxacin and norfloxacin against Neisseria gonorrhoeae, Haemophilus ducreyi, and Chlamydia trachomatis.

Authors: L Slaney; H Chubb; A Ronald; R Brunham
Journal: J Antimicrob Chemother Date: 1990-01 Impact factor: 5.790

4. In vitro and in vivo antibacterial activities of AT-4140, a new broad-spectrum quinolone.

Authors: S Nakamura; A Minami; K Nakata; N Kurobe; K Kouno; Y Sakaguchi; S Kashimoto; H Yoshida; T Kojima; T Ohue
Journal: Antimicrob Agents Chemother Date: 1989-08 Impact factor: 5.191

5. A prospective single-blind trial of minocycline and doxycycline in the treatment of genital Chlamydia trachomatis infection in women.

Authors: G T Kovacs; M Westcott; J Rusden; V Asche; H King; S E Haynes; E K Moore; B E Hall
Journal: Med J Aust Date: 1989-05-01 Impact factor: 7.738

In vitro and in vivo activities of sparfloxacin, other quinolones, and tetracyclines against Chlamydia trachomatis.

1. Renal handling of fleroxacin in rabbits, dogs, and humans.

Review 2. Chlamydial infections (third of three parts).

3. In-vitro activity of azithromycin, erythromycin, ciprofloxacin and norfloxacin against Neisseria gonorrhoeae, Haemophilus ducreyi, and Chlamydia trachomatis.

4. In vitro and in vivo antibacterial activities of AT-4140, a new broad-spectrum quinolone.

5. A prospective single-blind trial of minocycline and doxycycline in the treatment of genital Chlamydia trachomatis infection in women.

6. Treatment of nongonococcal urethritis with ciprofloxacin.

7. Ofloxacin: therapeutic results in Chlamydia trachomatis urethritis.

8. Evaluation of doxycycline in the treatment of urethritis and cervicitis caused by Chlamydia trachomatis.

9. Activities of new quinoline derivatives against genital pathogens.

10. Pharmacokinetics and tissue penetration of enoxacin.

1. Antibiotic susceptibilities of Parachlamydia acanthamoeba in amoebae.

2. Tissue penetration of sparfloxacin in a rat model of experimental Escherichia coli epididymitis.

3. Protective effects of sparfloxacin in experimental pneumonia caused by Chlamydia pneumoniae in leukopenic mice.

Review 4. Enoxacin: a reappraisal of its clinical efficacy in the treatment of genitourinary tract infections.

Review 5. Quinolones in intracellular infections.

6. In vitro and in vivo antichlamydial activities of newly developed quinolone antimicrobial agents.

Review 7. Quinolones in sexually transmitted diseases. Global experience.

Review 8. Fleroxacin. A review of its pharmacology and therapeutic efficacy in various infections.