Literature DB >> 1315795

Immunomodulatory effect of peripheral benzodiazepine receptor ligands on human mononuclear cells.

H Bessler1, R Weizman, M Gavish, I Notti, M Djaldetti.   

Abstract

Immunomodulatory effect of ligands active at the peripheral benzodiazepine receptor (PBR) was examined in human peripheral blood mononuclear cells (PBMC). Ro5-4864, PK11195 and diazepam suppressed phytohemagglutinin (PHA) and concanavalin A (ConA) induced proliferation of PBMC. All three ligands inhibited interleukin-3-like activity (IL-3-LA) secretion, while the production of interleukin-2 (IL-2) was inhibited by Ro5-4864 and diazepam only. The selective central benzodiazepine ligand clonazepam did not affect the cellular immune functions examined. Our results indicate an in-vitro immuno-suppressive activity of peripheral and mixed, but not central type benzodiazepine ligands.

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Year:  1992        PMID： 1315795     DOI： 10.1016/0165-5728(92)90086-z

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  8 in total

1.  Diazepam-mediated inhibition of human immunodeficiency virus type 1 expression in human brain cells.

Authors:  J R Lokensgard; G Gekker; S Hu; A F Arthur; C C Chao; P K Peterson
Journal:  Antimicrob Agents Chemother       Date:  1997-11       Impact factor: 5.191

2.  Diazepam inhibits HIV-1 Tat-induced migration of human microglia.

Authors:  J R Lokensgard; S Hu; C C Hegg; S A Thayer; G Gekker; P K Peterson
Journal:  J Neurovirol       Date:  2001-10       Impact factor: 2.643

3.  Effect of peripheral benzodiazepine receptor ligands on lipopolysaccharide-induced tumor necrosis factor activity in thioglycolate-treated mice.

Authors:  T Matsumoto; M Ogata; K Koga; A Shigematsu
Journal:  Antimicrob Agents Chemother       Date:  1994-04       Impact factor: 5.191

Review 4.  Benzodiazepines, glia, and HIV-1 neuropathogenesis.

Authors:  J R Lokensgard; C C Chao; G Gekker; S Hu; P K Peterson
Journal:  Mol Neurobiol       Date:  1998-08       Impact factor: 5.590

5.  An analysis of peripheral type benzodiazepine receptors on blood mononuclear cells during high dose steroid treatment of multiple sclerosis.

Authors:  P Ferrero; P Rocca; P Benna; C De Leo; E Montalenti; L Ravizza; B Bergamasco
Journal:  Ital J Neurol Sci       Date:  1992-11

6.  The translocator protein (TSPO) ligand PK11195 induces apoptosis and cell cycle arrest and sensitizes to chemotherapy treatment in pre- and post-relapse neuroblastoma cell lines.

Authors:  Maria C Mendonça-Torres; Stephen S Roberts
Journal:  Cancer Biol Ther       Date:  2013-01-28       Impact factor: 4.742

7.  Modifications of diazepam binding inhibitor and peripheral benzodiazepine receptors in the lymphocytes of epileptic patients.

Authors:  C Ferrarese; M Perego; C Marzorati; G Bianchi; M Frigo; N Pecora; R Riva; G Moretti; L Frattola
Journal:  Ital J Neurol Sci       Date:  1996-04

8.  Spinal translocator protein (TSPO) modulates pain behavior in rats with CFA-induced monoarthritis.

Authors:  Hayley Hernstadt; Shuxing Wang; Grewo Lim; Jianren Mao
Journal:  Brain Res       Date:  2009-06-23       Impact factor: 3.252
  8 in total

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