Literature DB >> 13130386

Pharmacokinetics of Ginkgo biloba extracts.

A Biber1.   

Abstract

EGb 761 (definition see editorial) Ginkgo extract is produced by a validated production process. Its pharmacologically active constituents, flavonol glycosides and terpene lactones, are kept within a narrow range of 22 to 27 % and 5 to 7 %, respectively, by standardisation. The concentration of ginkgolic acids is below 5 ppm. The constant production process also maintains the concentrations of other constituents such as proanthocyanidins, carboxylic acids and non-flavone glycosides at a fairly constant level. In this article, we will summarise the data on the pharmacokinetics of flavonol glycosides and terpene lactones.

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Year:  2003        PMID: 13130386     DOI: 10.1055/s-2003-40446

Source DB:  PubMed          Journal:  Pharmacopsychiatry        ISSN: 0176-3679            Impact factor:   5.788


  14 in total

1.  Systemic and cerebral exposure to and pharmacokinetics of flavonols and terpene lactones after dosing standardized Ginkgo biloba leaf extracts to rats via different routes of administration.

Authors:  Feng Chen; Li Li; Fang Xu; Yan Sun; Feifei Du; Xutao Ma; Chenchun Zhong; Xiuxue Li; Fengqing Wang; Nating Zhang; Chuan Li
Journal:  Br J Pharmacol       Date:  2013-09       Impact factor: 8.739

2.  Systemic exposure to Ginkgo biloba extract in male F344/NCrl rats: Relevance to humans.

Authors:  Suramya Waidyanatha; Esra Mutlu; Seth Gibbs; Billie Stiffler; Jon Andre; Brian Burback; Cynthia V Rider
Journal:  Food Chem Toxicol       Date:  2019-06-14       Impact factor: 6.023

3.  Neuroprotective effects of bilobalide are accompanied by a reduction of ischemia-induced glutamate release in vivo.

Authors:  Dorothee Lang; Cornelia Kiewert; Alexander Mdzinarishvili; Tina Maria Schwarzkopf; Rachita Sumbria; Joachim Hartmann; Jochen Klein
Journal:  Brain Res       Date:  2011-10-06       Impact factor: 3.252

Review 4.  Polyphenols in cerebral ischemia: novel targets for neuroprotection.

Authors:  Agnes Simonyi; Qun Wang; Rebecca L Miller; Mozow Yusof; Phullara B Shelat; Albert Y Sun; Grace Y Sun
Journal:  Mol Neurobiol       Date:  2005       Impact factor: 5.590

5.  Effects of Ginkgo biloba extracts on diazepam metabolism: a pharmacokinetic study in healthy Chinese male subjects.

Authors:  Xiao-Cong Zuo; Bi-Kui Zhang; Su-Jie Jia; Shi-Kun Liu; Ling-Yun Zhou; Jing Li; Jie Zhang; Ling-Ling Dai; Ben-Mei Chen; Guo-Ping Yang; Hong Yuan
Journal:  Eur J Clin Pharmacol       Date:  2010-02-26       Impact factor: 2.953

6.  Role of GABAergic antagonism in the neuroprotective effects of bilobalide.

Authors:  Cornelia Kiewert; Vikas Kumar; Oksana Hildmann; Misty Rueda; Joachim Hartmann; Runa S Naik; Jochen Klein
Journal:  Brain Res       Date:  2006-11-28       Impact factor: 3.252

Review 7.  Ginkgo biloba extract in Alzheimer's disease: from action mechanisms to medical practice.

Authors:  Chun Shi; Jun Liu; Fengming Wu; David T Yew
Journal:  Int J Mol Sci       Date:  2010-01-08       Impact factor: 5.923

Review 8.  Ginkgo biloba extracts: a review of the pharmacokinetics of the active ingredients.

Authors:  Christian Ude; Manfred Schubert-Zsilavecz; Mario Wurglics
Journal:  Clin Pharmacokinet       Date:  2013-09       Impact factor: 6.447

9.  The in vivo synaptic plasticity mechanism of EGb 761-induced enhancement of spatial learning and memory in aged rats.

Authors:  Yongfu Wang; Lei Wang; Jing Wu; Jingxia Cai
Journal:  Br J Pharmacol       Date:  2006-05       Impact factor: 8.739

10.  Gene Regulatory Effects of Ginkgo biloba Extract and Its Flavonol and Terpenelactone Fractions in Mouse Brain.

Authors:  Sabine Augustin; Gerald Rimbach; Kay Augustin; Rainer Cermak; Siegfried Wolffram
Journal:  J Clin Biochem Nutr       Date:  2009-10-28       Impact factor: 3.114

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