Literature DB >> 13129387

Synthesis and evaluation of water-soluble polymeric bone-targeted drug delivery systems.

Dong Wang1, Scott Miller, Monika Sima, Pavla Kopecková, Jindrich Kopecek.   

Abstract

Four polymeric bone-targeting conjugates were synthesized based on poly(ethylene glycol) (PEG, two conjugates) and poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA, two conjugates). The well-known bone-targeting compounds, alendronate and aspartic acid peptide, were used as bone-targeting moieties. Fluorescein isothiocyanate (FITC) was attached to the conjugates as a model drug for detection purposes. The bone-targeting potential of these conjugates was tested in vitro with hydroxyapatite (HA) and in mice. The data obtained indicated that these novel delivery systems could specifically accumulate in the bone tissue.

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Year:  2003        PMID： 13129387     DOI： 10.1021/bc034090j

Source DB:  PubMed          Journal:  Bioconjug Chem        ISSN： 1043-1802            Impact factor:   4.774


  33 in total

1.  Prevention of orthopedic device-associated osteomyelitis using oxacillin-containing biomineral-binding liposomes.

Authors:  Xin-Ming Liu; Yijia Zhang; Fu Chen; Irine Khutsishvili; Edward V Fehringer; Luis A Marky; Kenneth W Bayles; Dong Wang
Journal:  Pharm Res       Date:  2012-06-26       Impact factor: 4.200

2.  A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy.

Authors:  Ge Zhang; Baosheng Guo; Heng Wu; Tao Tang; Bao-Ting Zhang; Lizhen Zheng; Yixin He; Zhijun Yang; Xiaohua Pan; Heelum Chow; Kinwah To; Yaping Li; Dahu Li; Xinluan Wang; Yixiang Wang; Kwongman Lee; Zhibo Hou; Nan Dong; Gang Li; Kwoksui Leung; Leungkim Hung; Fuchu He; Lingqiang Zhang; Ling Qin
Journal:  Nat Med       Date:  2012-01-29       Impact factor: 53.440

3.  Biopolymer-based delivery systems for advanced imaging and skeletal tissue-specific therapeutics.

Authors:  Scott C Miller; Dong Wang; Pavla Kopecková; Jindrich Kopecek
Journal:  J Bone Miner Metab       Date:  2005       Impact factor: 2.626

Review 4.  RNA therapeutics targeting osteoclast-mediated excessive bone resorption.

Authors:  Yuwei Wang; David W Grainger
Journal:  Adv Drug Deliv Rev       Date:  2011-09-10       Impact factor: 15.470

5.  Synthesis, characterization and biodistribution studies of (125)I-radioiodinated di-PEGylated bone targeting salmon calcitonin analogue in healthy rats.

Authors:  Yang Yang; Krishna H Bhandari; Arash Panahifar; Michael R Doschak
Journal:  Pharm Res       Date:  2013-12-20       Impact factor: 4.200

6.  Multivalent Presentation of Peptide Targeting Groups Alters Polymer Biodistribution to Target Tissues.

Authors:  Maureen R Newman; Steven G Russell; Christopher S Schmitt; Ian A Marozas; Tzong-Jen Sheu; J Edward Puzas; Danielle S W Benoit
Journal:  Biomacromolecules       Date:  2017-12-28       Impact factor: 6.988

7.  In vivo imaging of bone using a deep-red fluorescent molecular probe bearing multiple iminodiacetate groups.

Authors:  Kara M Harmatys; Erin L Cole; Bradley D Smith
Journal:  Mol Pharm       Date:  2013-10-22       Impact factor: 4.939

Review 8.  Beyond oncology--application of HPMA copolymers in non-cancerous diseases.

Authors:  Xin-Ming Liu; Scott C Miller; Dong Wang
Journal:  Adv Drug Deliv Rev       Date:  2009-11-10       Impact factor: 15.470

9.  Water-soluble polymer-drug conjugates for combination chemotherapy against visceral leishmaniasis.

Authors:  Salvatore Nicoletti; Karin Seifert; Ian H Gilbert
Journal:  Bioorg Med Chem       Date:  2010-03-02       Impact factor: 3.641

10.  Stability in plasmas of various species of HPMA copolymer-PGE1 conjugates.

Authors:  Huaizhong Pan; Pavla Kopecková; Jihua Liu; Dong Wang; Scott C Miller; Jindrich Kopecek
Journal:  Pharm Res       Date:  2007-09-25       Impact factor: 4.200
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