Literature DB >> 1311370

Identification and characterization of the virion-induced host shutoff product of herpes simplex virus gene UL41.

C A Smibert1, D C Johnson, J R Smiley.   

Abstract

The virion-induced host shutoff product of the herpes simplex virus UL41 gene is required for shutoff of host translation and degradation of cellular mRNAs. We employed a rabbit antipeptide antiserum to identify a 58K UL41-related phosphoprotein in infected cells. We also provide evidence that this protein is a component of the virus particle, consistent with its role in virion-induced shutoff.

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Year:  1992        PMID： 1311370     DOI： 10.1099/0022-1317-73-2-467

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  55 in total

1.  Picornavirus internal ribosome entry site elements target RNA cleavage events induced by the herpes simplex virus virion host shutoff protein.

Authors:  M M Elgadi; J R Smiley
Journal:  J Virol       Date:  1999-11       Impact factor: 5.103

2.  Deletion of the virion host shutoff protein (vhs) from herpes simplex virus (HSV) relieves the viral block to dendritic cell activation: potential of vhs- HSV vectors for dendritic cell-mediated immunotherapy.

Authors:  Laila Samady; Emanuela Costigliola; Luci MacCormac; Yvonne McGrath; Steve Cleverley; Caroline E Lilley; Jill Smith; David S Latchman; Benny Chain; Robert S Coffin
Journal:  J Virol       Date:  2003-03       Impact factor: 5.103

3.  Assembly of infectious Herpes simplex virus type 1 virions in the absence of full-length VP22.

Authors:  L E Pomeranz; J A Blaho
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

4.  The virion host shutoff protein of herpes simplex virus type 1 has RNA degradation activity in primary neurons.

Authors:  Stephanie S Strand; Tambryn K Vanheyningen; David A Leib
Journal:  J Virol       Date:  2004-08       Impact factor: 5.103

5.  The virion host shutoff endonuclease (UL41) of herpes simplex virus interacts with the cellular cap-binding complex eIF4F.

Authors:  Heidi G Page; G Sullivan Read
Journal:  J Virol       Date:  2010-04-28       Impact factor: 5.103

6.  Role of the VP16-binding domain of vhs in viral growth, host shutoff activity, and pathogenesis.

Authors:  Stephanie S Strand; David A Leib
Journal:  J Virol       Date:  2004-12       Impact factor: 5.103

7.  The herpes simplex virus type 1 vhs-UL41 gene secures viral replication by temporarily evading apoptotic cellular response to infection: Vhs-UL41 activity might require interactions with elements of cellular mRNA degradation machinery.

Authors:  Ari Barzilai; Ifaat Zivony-Elbom; Ronit Sarid; Eran Noah; Niza Frenkel
Journal:  J Virol       Date:  2006-01       Impact factor: 5.103

8.  mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A.

Authors:  Pinghui Feng; David N Everly; G Sullivan Read
Journal:  J Virol       Date:  2005-08       Impact factor: 5.103

9.  Role of the virion host shutoff (vhs) of herpes simplex virus type 1 in latency and pathogenesis.

Authors:  L I Strelow; D A Leib
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

10.  Induction of interleukin-8 gene expression is associated with herpes simplex virus infection of human corneal keratocytes but not human corneal epithelial cells.

Authors:  J E Oakes; C A Monteiro; C L Cubitt; R N Lausch
Journal:  J Virol       Date:  1993-08       Impact factor: 5.103
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