Literature DB >> 1310784

Simian virus 40 (SV40) small t antigen inhibits SV40 DNA replication in vitro.

M Carbone1, J Hauser, M P Carty, K Rundell, K Dixon, A S Levine.   

Abstract

We describe a biochemical function of simian virus 40 small t antigen, the inhibition of simian virus 40 large T antigen-mediated viral DNA replication in an in vitro replication system. Our results suggest that in this system, small t antigen prevents protein phosphatase 2A-mediated activation of large T antigen.

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Year:  1992        PMID： 1310784      PMCID： PMC240946     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  28 in total

1.  New region of the simian virus 40 genome required for efficient viral transformation.

Authors:  N Bouck; N Beales; T Shenk; P Berg; G di Mayorca
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205

2.  Mutants of SV40 with an altered small t protein are reduced in their ability to transform cells.

Authors:  M J Sleigh; W C Topp; R Hanich; J F Sambrook
Journal:  Cell       Date:  1978-05       Impact factor: 41.582

3.  Replication and supercoiling of simian virus 40 DNA in cell extracts from human cells.

Authors:  B W Stillman; Y Gluzman
Journal:  Mol Cell Biol       Date:  1985-08       Impact factor: 4.272

4.  Complete interaction of cellular 56,000- and 32,000-Mr proteins with simian virus 40 small-t antigen in productively infected cells.

Authors:  K Rundell
Journal:  J Virol       Date:  1987-04       Impact factor: 5.103

5.  The roles of the simian virus 40 tumor antigens in transformation of Chinese hamster lung cells.

Authors:  R G Martin; V P Setlow; C A Edwards; D Vembu
Journal:  Cell       Date:  1979-07       Impact factor: 41.582

6.  Simian virus 40 small t antigen is not required for the maintenance of transformation but may act as a promoter (cocarcinogen) during establishment of transformation in resting rat cells.

Authors:  R Seif; R G Martin
Journal:  J Virol       Date:  1979-12       Impact factor: 5.103

7.  Control of protein phosphatase 2A by simian virus 40 small-t antigen.

Authors:  S I Yang; R L Lickteig; R Estes; K Rundell; G Walter; M C Mumby
Journal:  Mol Cell Biol       Date:  1991-04       Impact factor: 4.272

8.  Purification of replication protein C, a cellular protein involved in the initial stages of simian virus 40 DNA replication in vitro.

Authors:  D M Virshup; T J Kelly
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

9.  Fidelity of DNA synthesis in a mammalian in vitro replication system.

Authors:  J Hauser; A S Levine; K Dixon
Journal:  Mol Cell Biol       Date:  1988-08       Impact factor: 4.272

10.  Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A.

Authors:  D M Virshup; M G Kauffman; T J Kelly
Journal:  EMBO J       Date:  1989-12-01       Impact factor: 11.598
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  7 in total

1.  JC virus small T antigen binds phosphatase PP2A and Rb family proteins and is required for efficient viral DNA replication activity.

Authors:  Brigitte Bollag; Catherine A Hofstetter; Marta M Reviriego-Mendoza; Richard J Frisque
Journal:  PLoS One       Date:  2010-05-12       Impact factor: 3.240

2.  Simian virus 40 small-t antigen stimulates viral DNA replication in permissive monkey cells.

Authors:  C Cicala; M L Avantaggiati; A Graessmann; K Rundell; A S Levine; M Carbone
Journal:  J Virol       Date:  1994-05       Impact factor: 5.103

3.  Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirus.

Authors:  R Ruediger; D Roeckel; J Fait; A Bergqvist; G Magnusson; G Walter
Journal:  Mol Cell Biol       Date:  1992-11       Impact factor: 4.272

4.  Simian virus 40 small-t antigen binds two zinc ions.

Authors:  B Turk; A Porras; M C Mumby; K Rundell
Journal:  J Virol       Date:  1993-06       Impact factor: 5.103

5.  SV40 induces mesotheliomas in hamsters.

Authors:  C Cicala; F Pompetti; M Carbone
Journal:  Am J Pathol       Date:  1993-05       Impact factor: 4.307

6.  Simian virus 40 small tumor antigen inhibits dephosphorylation of protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation.

Authors:  W H Wheat; W J Roesler; D J Klemm
Journal:  Mol Cell Biol       Date:  1994-09       Impact factor: 4.272

Review 7.  Gene Regulation and Quality Control in Murine Polyomavirus Infection.

Authors:  Gordon G Carmichael
Journal:  Viruses       Date:  2016-10-17       Impact factor: 5.048
  7 in total

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