Literature DB >> 1310721

Increased superoxide dismutase activity in aged human cerebrospinal fluid and rat brain determined by electron spin resonance spectrometry using the spin trap method.

M Hiramatsu1, M Kohno, R Edamatsu, K Mitsuta, A Mori.   

Abstract

Superoxide dismutase (SOD) activity in CSF of patients was determined by electron spin resonance spectrometry using the spin trap method. Variation in SOD activity was found among patients. SOD activity in CSF of subjects increased with age and this was identified as Cu,Zn-SOD activity by electrophoresis. In addition, animal experiments showed that SOD activities were higher in mitochondrial and cytosol fractions of aged rats than in those of adult rats. This finding on aged rat brain validates the increase of SOD activity in aged human CSF.

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Year:  1992        PMID： 1310721     DOI： 10.1111/j.1471-4159.1992.tb09375.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  6 in total

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Authors:  J K Yao; R D Reddy; D P van Kammen
Journal:  CNS Drugs       Date:  2001       Impact factor: 5.749

2.  Free radical scavenging activity of the Japanese herbal medicine toki-shakuyaku-san (TJ-23) and its effect on superoxide dismutase activity, lipid peroxides, glutamate, and monoamine metabolites in aged rat brain.

Authors:  Y Ueda; M Komatsu; M Hiramatsu
Journal:  Neurochem Res       Date:  1996-08       Impact factor: 3.996

Review 3.  Stress, aging, and brain oxidative damage.

Authors:  J Liu; A Mori
Journal:  Neurochem Res       Date:  1999-11       Impact factor: 3.996

4.  Applications of electron spin resonance spectrometry for reactive oxygen species and reactive nitrogen species research.

Authors:  Masahiro Kohno
Journal:  J Clin Biochem Nutr       Date:  2010-06-18       Impact factor: 3.114

5.  Age-related increases in superoxide dismutase activity and thiobarbituric acid-reactive substances: effect of bio-catalyzer in aged rat brain.

Authors:  L A Santiago; J A Osato; J Liu; A Mori
Journal:  Neurochem Res       Date:  1993-06       Impact factor: 3.996

6.  Multiple free-radical scavenging capacity in serum.

Authors:  Shigeru Oowada; Nobuyuki Endo; Hiromi Kameya; Masashi Shimmei; Yashige Kotake
Journal:  J Clin Biochem Nutr       Date:  2012-05-11       Impact factor: 3.114
  6 in total

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