Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The open reading frames in the 3' long terminal repeats of several mouse mammary tumor virus integrants encode V beta 3-specific superantigens.

Literature DB >> 1309854

The open reading frames in the 3' long terminal repeats of several mouse mammary tumor virus integrants encode V beta 3-specific superantigens.

A M Pullen¹, Y Choi, E Kushnir, J Kappler, P Marrack.

Abstract

Mice expressing the minor lymphocyte stimulation antigens, Mls-1a, -2a, or -3a, singly on the B10.BR background have been generated. Mls phenotypes correlate with the integration of mouse mammary tumor viruses (MTV) in the mouse genome. The open reading frames within the 3' long terminal repeats of the integrated MTVs 1, 3, 6, and 13 encode V beta 3-specific superantigens. Sequence data for these viral superantigens is presented, indicating that it is the COOH-terminal portion of the viral superantigen that interacts with the T cell receptor V beta element.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1992 PMID： 1309854 PMCID： PMC2119085 DOI： 10.1084/jem.175.1.41

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

36 in total

Review 1. Tolerance to self antigens shapes the T-cell repertoire.

Authors: A M Pullen; J W Kappler; P Marrack
Journal: Immunol Rev Date: 1989-02 Impact factor: 12.988

2. A T cell receptor V beta segment that imparts reactivity to a class II major histocompatibility complex product.

Authors: J W Kappler; T Wade; J White; E Kushnir; M Blackman; J Bill; N Roehm; P Marrack
Journal: Cell Date: 1987-04-24 Impact factor: 41.582

3. The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens.

Authors: A M Pullen; P Marrack; J W Kappler
Journal: Nature Date: 1988-10-27 Impact factor: 49.962

4. T cell tolerance by clonal elimination in the thymus.

Authors: J W Kappler; N Roehm; P Marrack
Journal: Cell Date: 1987-04-24 Impact factor: 41.582

5. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

Authors: A P Feinberg; B Vogelstein
Journal: Anal Biochem Date: 1983-07-01 Impact factor: 3.365

6. Molecular cloning and sequencing of the MTV-1 LTR: evidence for a LTR sequence alteration.

Authors: C A Crouse; R J Pauley
Journal: Virus Res Date: 1989-02 Impact factor: 3.303

7. Construction of a clonable, infectious, and tumorigenic mouse mammary tumor virus provirus and a derivative genetic vector.

Authors: G M Shackleford; H E Varmus
Journal: Proc Natl Acad Sci U S A Date: 1988-12 Impact factor: 11.205

Review 5. Virus-encoded superantigens.

Authors: B T Huber; P N Hsu; N Sutkowski
Journal: Microbiol Rev Date: 1996-09

Review 6. Superantigens related to B cell hyperplasia.

Authors: N M Ponzio; V K Tsiagbe; G J Thorbecke
Journal: Springer Semin Immunopathol Date: 1996

7. Coexpression of exogenous and endogenous mouse mammary tumor virus RNA in vivo results in viral recombination and broadens the virus host range.

Authors: T V Golovkina; A B Jaffe; S R Ross
Journal: J Virol Date: 1994-08 Impact factor: 5.103

The open reading frames in the 3' long terminal repeats of several mouse mammary tumor virus integrants encode V beta 3-specific superantigens.

Review 1. Tolerance to self antigens shapes the T-cell repertoire.

2. A T cell receptor V beta segment that imparts reactivity to a class II major histocompatibility complex product.

3. The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens.

4. T cell tolerance by clonal elimination in the thymus.

5. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

6. Molecular cloning and sequencing of the MTV-1 LTR: evidence for a LTR sequence alteration.

7. Construction of a clonable, infectious, and tumorigenic mouse mammary tumor virus provirus and a derivative genetic vector.

8. Linkage of Mls genes to endogenous mammary tumour viruses of inbred mice.

9. Regulatory and coding potential of the mouse mammary tumor virus long terminal redundancy.

10. The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cells.

1. Altered thymic positive selection and intracellular signals in Cbl-deficient mice.

2. New superantigen specificity created by two amino acid replacements.

Review 3. The potential role of superantigens in inflammatory bowel disease.

4. Tcrb-V12-specific superantigens encoded by mouse mammary tumor proviruses.

Review 5. Virus-encoded superantigens.

Review 6. Superantigens related to B cell hyperplasia.

7. Coexpression of exogenous and endogenous mouse mammary tumor virus RNA in vivo results in viral recombination and broadens the virus host range.

8. Mouse mammary tumor virus-induced tumorigenesis in sag transgenic mice: a laboratory model of natural selection.

9. Mammary gland expression of mouse mammary tumor virus is regulated by a novel element in the long terminal repeat.

Review 10. Role of the T cell receptor alpha-chain in superantigen recognition.