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Literature DB >> 1309226

Topoisomerase II alpha and topoisomerase II beta genes: characterization and mapping to human chromosomes 17 and 3, respectively.

K B Tan¹, T E Dorman, K M Falls, T D Chung, C K Mirabelli, S T Crooke, J Mao.

Abstract

Human cells contain two topoisomerase II isozymes named topo II alpha and topo II beta. The complementary DNAs for both enzymes have been cloned. The topo II alpha and topo II beta complementary DNAs hybridized to unique sequences of human, rodent, and chicken DNAs in Southern blots. The human topo II alpha gene has previously been mapped to chromosome 17. We confirmed the chromosomal location of topo II alpha and mapped the topo II beta gene to chromosome 3. In addition, topo II beta exhibits genetic polymorphism as has been reported for topoisomerases I and II alpha.

Entities: Gene Species

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Year: 1992 PMID： 1309226

Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701

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Cited

49 in total

1. The topoisomerase IIbeta circular clamp arrests transcription and signals a 26S proteasome pathway.

Authors: Hai Xiao; Yong Mao; Shyamal D Desai; Nai Zhou; Chun-Yuan Ting; Jaulang Hwang; Leroy F Liu
Journal: Proc Natl Acad Sci U S A Date: 2003-03-10 Impact factor: 11.205

2. Endonuclease G interacts with histone H2B and DNA topoisomerase II alpha during apoptosis.

Authors: Miroslav Vařecha; Michaela Potěšilová; Pavel Matula; Michal Kozubek
Journal: Mol Cell Biochem Date: 2011-12-08 Impact factor: 3.396

Review 3. The function of DNA topoisomerase IIβ in neuronal development.

Authors: Xin Heng; Wei-Dong Le
Journal: Neurosci Bull Date: 2010-10 Impact factor: 5.203

4. Tyrosine 656 in topoisomerase IIβ is important for the catalytic activity of the enzyme: Identification based on artifactual +80-Da modification at this site.

Authors: Adrian G Grozav; Belinda B Willard; Toshiyuki Kozuki; Kenichi Chikamori; Marius A Micluta; Andrei-Jose Petrescu; Michael Kinter; Ram Ganapathi; Mahrukh K Ganapathi
Journal: Proteomics Date: 2011-01-31 Impact factor: 3.984

5. Proliferation-associated nuclear antigen Ki-S1 is identical with topoisomerase II alpha. Delineation of a carboxy-terminal epitope with peptide antibodies.

Authors: F Boege; A Andersen; S Jensen; R Zeidler; H Kreipe
Journal: Am J Pathol Date: 1995-06 Impact factor: 4.307

10. Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.

Authors: Ryan P Bender; Michael J Jablonksy; Mohammad Shadid; Ian Romaine; Norma Dunlap; Clemens Anklin; David E Graves; Neil Osheroff
Journal: Biochemistry Date: 2008-03-21 Impact factor: 3.162

Topoisomerase II alpha and topoisomerase II beta genes: characterization and mapping to human chromosomes 17 and 3, respectively.

1. The topoisomerase IIbeta circular clamp arrests transcription and signals a 26S proteasome pathway.

2. Endonuclease G interacts with histone H2B and DNA topoisomerase II alpha during apoptosis.

Review 3. The function of DNA topoisomerase IIβ in neuronal development.

4. Tyrosine 656 in topoisomerase IIβ is important for the catalytic activity of the enzyme: Identification based on artifactual +80-Da modification at this site.

5. Proliferation-associated nuclear antigen Ki-S1 is identical with topoisomerase II alpha. Delineation of a carboxy-terminal epitope with peptide antibodies.

6. Organization of DNA topoisomerase II isotypes during the cell cycle of human lymphocytes and HeLa cells.

7. CORRELATIONSHIP OF CATHEPSIN D AND TOPOISOMERASE II ALPHA WITH NUCLEAR GRADING IN BREAST CANCERS.

8. Functional interaction between human topoisomerase IIalpha and retinoblastoma protein.

9. (-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases.

10. Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.