Literature DB >> 13084846

The influence of calcium ions on the inactivation of human complement and its components by plasmin.

I H LEPOW, L PILLEMER, O D RATNOFF.   

Abstract

Ca(++) potentiates the inactivation of human complement by streptokinase-activated plasmin and chloroform-activated bovine plasmin. The optimum concentration of Ca(++) varies between 10(-2)M and 10(-3)M, decreasing with increasing concentrations of streptokinase. The susceptibility of the components of complement to inactivation by plasmin is different in the presence and absence of Ca(++). C'2 and C'4 are most readily inactivated by plasmin in the presence of Ca(++), while C'1 disappears first in the absence of Ca(++). A large part of this C'1 disappearance is due to spontaneous inactivation. Similarities are pointed out between the influence of Ca(++) on the inactivation of the components of complement by antigen-antibody systems and by plasmin.

Entities:  

Keywords:  CALCIUM/effects; COMPLEMENT; FIBRINOLYSIN/effects

Mesh：

Substances：

Year:  1953        PMID： 13084846      PMCID： PMC2136238          DOI： 10.1084/jem.98.3.277

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  8 in total

1.  [Calcium and alexin].

Authors:  O GENGOU
Journal:  Ann Inst Pasteur (Paris)       Date:  1952-11

2.  Calcium and Complement Action.

Authors:  J Gordon; H R Whitehead; A Wormall
Journal:  Biochem J       Date:  1926       Impact factor: 3.857

3.  STUDIES ON BLOOD COAGULATION: A PROTEOLYTIC ENZYME PREPARED FROM CALCIUM AND PLATELET FREE NORMAL HUMAN BLOOD PLASMA.

Authors:  H J Tagnon; C S Davidson; F H Taylor
Journal:  J Clin Invest       Date:  1942-09       Impact factor: 14.808

4.  THE TERMINOLOGY OF THE COMPONENTS OF COMPLEMENT.

Authors:  L Pillemer; E E Ecker
Journal:  Science       Date:  1941-11-07       Impact factor: 47.728

5.  The inactivation of complement and its components by plasmin.

Authors:  L PILLEMER; O D RATNOFF; L BLUM; I H LEPOW
Journal:  J Exp Med       Date:  1953-04       Impact factor: 14.307

6.  Studies on a proteolytic enzyme in human plasma. VIII. The effect of calcium and strontium ions on the activation of the plasma proteolytic enzyme.

Authors:  O D RATNOFF
Journal:  J Exp Med       Date:  1952-05       Impact factor: 14.307

7.  A COMPARISON OF HUMAN AND GUINEA PIG COMPLEMENTS AND THEIR COMPONENT FRACTIONS.

Authors:  O G Bier; G Leyton; M M Mayer; M Heidelberger
Journal:  J Exp Med       Date:  1945-05-01       Impact factor: 14.307

8.  THE ACTIVATING EFFECT OF MAGNESIUM AND OTHER CATIONS ON THE HEMOLYTIC FUNCTION OF COMPLEMENT.

Authors:  M M Mayer; A G Osler; O G Bier; M Heidelberger
Journal:  J Exp Med       Date:  1946-11-30       Impact factor: 14.307
  8 in total
  13 in total

1.  Further studies on the effect of some anti-coagulants upon sero-diagnostic tests for syphilis. II. Heparin, thymol-fluoride, isotonic oxalate, and concentrated citrate solution.

Authors:  R D COLEMAN; M D APPLEMAN; H M KURTZ
Journal:  Br J Vener Dis       Date:  1955-06

2.  Studies of the reaction between the sensitized erythrocyte and the first component of complement.

Authors:  G H WIRTZ; E L BECKER
Journal:  Immunology       Date:  1961-10       Impact factor: 7.397

3.  The differentiation of the chloroform, peptone and antigen-antibody inducible esterase activities of human serum from plasmin.

Authors:  K F AUSTEN
Journal:  Immunology       Date:  1960-04       Impact factor: 7.397

4.  The properdin system and immunity. IV. The hemolysis of erythrocytes from patients with paroxysmal nocturnal hemoglobinuria.

Authors:  C F HINZ; W S JORDAN; L PILLEMER
Journal:  J Clin Invest       Date:  1956-05       Impact factor: 14.808

5.  The Role of Proaccelerin in Human Blood Coagulation. Evidence that Proaccelerin Is Converted to a Prothrombin-converting Principle by Activated Stuart Factor: With Notes on the Anticoagulant Action of Soybean Trypsin Inhibitor, Protamine Sulfate, and Hexadimethrine Bromide.

Authors:  R T Breckenridge; O D Ratnoff
Journal:  J Clin Invest       Date:  1965-02       Impact factor: 14.808

6.  C1r, subunit of the first complement component: purification, properties, and assay based on its linking role.

Authors:  M M De Bracco; R M Stroud
Journal:  J Clin Invest       Date:  1971-04       Impact factor: 14.808

7.  C1 inactivator inhibition by plasmin.

Authors:  P C Harpel
Journal:  J Clin Invest       Date:  1970-03       Impact factor: 14.808

8.  The release of histamine and 5-hydroxytryptamine (serotonin) from platelets by antigen-antibody reactions (in vitro).

Authors:  J H HUMPHREY; R JAQUES
Journal:  J Physiol       Date:  1955-04-28       Impact factor: 5.182

9.  Studies on the activation of a proesterase associated with partially purified first component of human complement.

Authors:  I H LEPOW; O D RATNOFF; L R LEVY
Journal:  J Exp Med       Date:  1958-03-01       Impact factor: 14.307

10.  Ionic requirements of Treponema pallidum. III. Divalent ions.

Authors:  G O DOAK; L D FREEDMAN; J W CLARK
Journal:  J Bacteriol       Date:  1961-12       Impact factor: 3.490
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