| Literature DB >> 19871586 |
M M Mayer1, A G Osler, O G Bier, M Heidelberger.
Abstract
1. The evidence presented indicates that Mg(++), or other cation such as Ca(++), Ni(++), or Co(++), is essential for the hemolytic action of C'. Ca(++), Ni(++), and Co(++) are less effective than Mg(++). The hemolytic system usually does not contain sufficient Mg(++) for optimal hemolytic activity so that a marked enhancement can be obtained by addition of extra Mg(++). 2. The enhancing action of tissue fluids can be ascribed to their contribution of Mg(++). 3. Substances which bind Mg(++) and Ca(++) are anticomplementary when added to the usual hemolytic system which contains only a small quantity of Mg(++). This type of anticomplementary effect can be overcome by addition of extra Mg(++). 4. Ca(++) may also be essential to the lytic process but its action is much less pronounced than that of Mg(++).Entities:
Keywords: COMPLEMENT
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Year: 1946 PMID： 19871586 PMCID： PMC2135623 DOI： 10.1084/jem.84.6.535
Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307