Literature DB >> 1306330

Antitumor activity of new antitumor substance, polyoxomolybdate, against several human cancers in athymic nude mice.

H Fujita1, T Fujita, T Sakurai, T Yamase, Y Seto.   

Abstract

Antitumor polyoxomolybdates have been recognized in the course of study on the medical utilization of polyoxometalates, inorganic polymers of metal oxide. [NH3Pri]6[Mo7O24].3H2O (PM-8) was found as a representative of antitumor polyoxomolybdates. The growth suppressions of PM-8 against Co-4 human colon cancer xenografted under the subrenal capsule in cd-1 mice were equal or superior to that of 5-FU, MMC, ACNU, ADM and CDDP. Potent antitumor activity of PM-8 is also established against MX-1 human breast and OAT human lung cancer xenografted in athymic nude mice. Polyoxomolybdate is a new type of antitumor substance.

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Year:  1992        PMID： 1306330     DOI： 10.1620/tjem.168.421

Source DB:  PubMed          Journal:  Tohoku J Exp Med        ISSN： 0040-8727            Impact factor:   1.848


  5 in total

1.  Cation-mediated optical resolution and anticancer activity of chiral polyoxometalates built from entirely achiral building blocks.

Authors:  Zhi-Ming Zhang; Xiaopin Duan; Shuang Yao; Zhishu Wang; Zekai Lin; Yang-Guang Li; La-Sheng Long; En-Bo Wang; Wenbin Lin
Journal:  Chem Sci       Date:  2016-03-09       Impact factor: 9.825

2.  The Aquaporin-3-Inhibiting Potential of Polyoxotungstates.

Authors:  Catarina Pimpão; Inês V da Silva; Andreia F Mósca; Jacinta O Pinho; Maria Manuela Gaspar; Nadiia I Gumerova; Annette Rompel; Manuel Aureliano; Graça Soveral
Journal:  Int J Mol Sci       Date:  2020-04-02       Impact factor: 5.923

3.  The First Anticancer Tris(pyrazolyl)borate Molybdenum(IV) Complexes: Tested in Vitro and in Vivo-A Comparison of O,O-, S,O-, and N,N-Chelate Effects.

Authors:  Iker Berasaluce; Klaudia Cseh; Alexander Roller; Michaela Hejl; Petra Heffeter; Walter Berger; Michael A Jakupec; Wolfgang Kandioller; Michael S Malarek; Bernhard K Keppler
Journal:  Chemistry       Date:  2019-11-19       Impact factor: 5.236

Review 4.  Polyoxometalates active against tumors, viruses, and bacteria.

Authors:  Toshihiro Yamase
Journal:  Prog Mol Subcell Biol       Date:  2013

5.  Antitumour effect of polyoxomolybdates: induction of apoptotic cell death and autophagy in in vitro and in vivo models.

Authors:  A Ogata; H Yanagie; E Ishikawa; Y Morishita; S Mitsui; A Yamashita; K Hasumi; S Takamoto; T Yamase; M Eriguchi
Journal:  Br J Cancer       Date:  2007-12-18       Impact factor: 7.640
  5 in total

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