Literature DB >> 129786

Human pituitary growth hormone. 44. Effects of plasmin-modified hormone and its fragments on ornithine decarboxylase activity and lipolysis.

A J Rao, J Ramachandran, C H Li.   

Abstract

The rat hepatic ornithine decarboxylase stimulating activity of plasmin-modified human growth hormone and its two peptide fragments has been investigated. The activity was completely retained after plasmin treatment. The NH2-terminal fragment [Cys (Cam)53-HGH-(1-134)] retained 10% of the activity, whereas the COOH-terminal fragment [Cys (Cam) 165, 182, 189-(141-191)] was not active. The lipolytic activity of human growth hormone was greatly reduced after plasmin treatment, as examined in isolated rabbit adipocytes. It is suggested that the structural requirements for the lipolytic activity of the hormone are different from those required for stimulation of ornithine decarboxylase activity.

Entities:  

Mesh：

Substances：

Year:  1976        PMID： 129786     DOI： 10.3181/00379727-151-39193

Source DB:  PubMed          Journal:  Proc Soc Exp Biol Med        ISSN： 0037-9727


  3 in total

1.  Preparation of a disulfide-linked dimer of human placental lactogen fragment 1--134 with immunologic and biologic activity.

Authors:  J Russell; L M Sherwood; K Kowalski; A B Schneider
Journal:  Proc Natl Acad Sci U S A       Date:  1979-03       Impact factor: 11.205

2.  Rate of concentration and digestion of radioactive growth hormone preparations injected in rats, as measured by the amount and nature of radioactivity in the tissues.

Authors:  L A Retegui-Sardou; L O Scaramal; J M Dellacha; A C Paladini
Journal:  Mol Cell Biochem       Date:  1977-07-05       Impact factor: 3.396

3.  Human somatotropin: biological characterization of the recombinant molecule.

Authors:  C H Li; T Hayashida; B A Doneen; A J Rao
Journal:  Proc Natl Acad Sci U S A       Date:  1976-10       Impact factor: 11.205
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.