Literature DB >> 12973946

Detection of embryo sex chromosome by dual color fluorescent in-situ hybridization.

Qun Liu1, Guijin Zhu.   

Abstract

In order to evaluate the effects of sex chromosomal mosaicism on the accuracy of single-cell gender diagnosis, sex chromosomes of 21 normal fertilized embryos were detected by dual color fluorescent in-situ hybridization (FISH). The results showed that 4 embryos had sex chromosomal mosaicism (19%) and the remaining 17 showed uniformly XX or XY signals in all blastomeres. In conclusion, identification of sex by dual color FISH analysis of a single cell was accurate and efficient, and sex chromosomal mosaicism would not affect preimplantation gender diagnosis.

Mesh：

Year:  2003        PMID： 12973946     DOI： 10.1007/BF02859953

Source DB:  PubMed          Journal:  J Huazhong Univ Sci Technolog Med Sci        ISSN： 1672-0733


  13 in total

1.  Clinical experience of sex determination by fluorescent in-situ hybridization for preimplantation genetic diagnosis.

Authors:  C Staessen; E Van Assche; H Joris; M Bonduelle; M Vandervorst; I Liebaers; A Van Steirteghem
Journal:  Mol Hum Reprod       Date:  1999-04       Impact factor: 4.025

2.  Mosaicism and aneuploidy in human preembryos.

Authors:  C M Strom
Journal:  J Assist Reprod Genet       Date:  1996-08       Impact factor: 3.412

3.  Cytogenetic analysis and developmental capacity of normal and abnormal embryos after IVF.

Authors:  M Plachot; J Mandelbaum; A M Junca; J de Grouchy; J Salat-Baroux; J Cohen
Journal:  Hum Reprod       Date:  1989-11       Impact factor: 6.918

4.  Multicolour FISH detects frequent chromosomal mosaicism and chaotic division in normal preimplantation embryos from fertile patients.

Authors:  J D Delhanty; J C Harper; A Ao; A H Handyside; R M Winston
Journal:  Hum Genet       Date:  1997-06       Impact factor: 4.132

5.  Mosaicism of autosomes and sex chromosomes in morphologically normal, monospermic preimplantation human embryos.

Authors:  J C Harper; E Coonen; A H Handyside; R M Winston; A H Hopman; J D Delhanty
Journal:  Prenat Diagn       Date:  1995-01       Impact factor: 3.050

6.  Chromosome mosaicism in human embryos.

Authors:  S Munné; H U Weier; J Grifo; J Cohen
Journal:  Biol Reprod       Date:  1994-09       Impact factor: 4.285

7.  Presence of chromosomal mosaicism in abnormal preimplantation embryos detected by fluorescence in situ hybridisation.

Authors:  E Coonen; J C Harper; F C Ramaekers; J D Delhanty; A H Hopman; J P Geraedts; A H Handyside
Journal:  Hum Genet       Date:  1994-12       Impact factor: 4.132

8.  Treatment-related chromosome abnormalities in human embryos.

Authors:  S Munne; C Magli; A Adler; G Wright; K de Boer; D Mortimer; M Tucker; J Cohen; L Gianaroli
Journal:  Hum Reprod       Date:  1997-04       Impact factor: 6.918

9.  In situ hybridization as a tool to study numerical chromosome aberrations in solid bladder tumors.

Authors:  A H Hopman; F C Ramaekers; A K Raap; J L Beck; P Devilee; M van der Ploeg; G P Vooijs
Journal:  Histochemistry       Date:  1988

10.  The chromosome constitution of human preimplantation embryos fertilized in vitro.

Authors:  M E Jamieson; J R Coutts; J M Connor
Journal:  Hum Reprod       Date:  1994-04       Impact factor: 6.918
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  1 in total

1.  Diagnosis of Sex Chromosome Disorders and Prenatal Diagnosis of Down Syndrome using Interphase Fluorescent In-Situ Hyperidization Technique.

Authors:  Ahmad Settin; Ibrahem S Abu-Saif; Rizk El-Baz; Moataz Dowaidar; Rabab Abu-Al Kasim; Shaimaa Shabana
Journal:  Int J Health Sci (Qassim)       Date:  2007-07
  1 in total

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