Literature DB >> 12968342

Novel imidazolination reaction of alkenes provides an easy access to new alpha,beta-differentiated 1,2-vicinal diamines.

Wei Pei1, Cody Timmons, Xin Xu, Han-Xun Wei, Guigen Li.   

Abstract

alpha,beta-Differentiated 1,2-vicinal diamines have been efficiently synthesized by using new electrophilic imidazolination reaction of alkenes. The hydrolysis of imidazolines was performed by treatment with 6 M HCl in THF at 70 degrees C without epimerization. Eight examples were examined to give good to excellent yields (87-96%).

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Year:  2003        PMID: 12968342     DOI: 10.1039/b305149h

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN: 1477-0520            Impact factor:   3.876


  2 in total

1.  Azomethine ylide mediated inversion of configuration of quaternary imidazoline carbon: converting trans- to its cis- imidazolines.

Authors:  Ke Qu; Jason S Fisk; Jetze J Tepe
Journal:  Tetrahedron Lett       Date:  2011-09-21       Impact factor: 2.415

2.  Methods for direct alkene diamination, new & old.

Authors:  Sam de Jong; Daniel G Nosal; Duncan J Wardrop
Journal:  Tetrahedron       Date:  2012-03-21       Impact factor: 2.457

  2 in total

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