| Literature DB >> 12958213 |
Ifat Rubin-Bejerano1, Iain Fraser, Paula Grisafi, Gerald R Fink.
Abstract
The transcriptional profiles of yeast cells that have been phagocytosed by either human neutrophils or monocytes were compared by using whole genome arrays. After phagocytosis by neutrophils, both Saccharomyces cerevisiae and Candida albicans respond by inducing genes of the methionine and arginine pathways. Neither of these pathways is induced upon phagocytosis by monocytes. Both fungi show a similar induction of these pathways when transferred from amino acid-rich medium to amino acid-deficient medium. These data suggest that the internal phagosome of the neutrophil is an amino acid-deficient environment.Entities:
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Year: 2003 PMID： 12958213 PMCID： PMC196917 DOI： 10.1073/pnas.1834481100
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205