BACKGROUND: The aetiology of atopic dermatitis (AD) is presumably multi-factorial, with interactions between genetic and environmental factors. OBJECTIVE: To investigate the relation between atopic family history and development of AD up to 4 years. METHODS: Using annual questionnaires, we studied the cumulative incidence of AD in 0-4-year-olds in a prospective birth cohort of 4089. Atopic diseases in parents and siblings were recorded at birth. The occurrence of serum immunoglobulin E (IgE) antibodies to inhalant and food allergens was analysed in 2614 4-year-olds, and AD was divided into non-IgE-associated and IgE-associated. RESULTS: Of the children without atopic parents, 27.1% developed AD; of those with single or double parental atopic history, 37.9% and 50.0%, respectively, did so. The effects of parental history of eczema and of atopic respiratory disease (ARD) did not differ significantly, nor did those of maternal and paternal history. Parental history of ARD increased the risk significantly more for IgE-associated AD than for non-IgE-associated AD (odds ratio (OR) 2.0; 95% confidence interval (CI) 1.5-2.8 vs. OR 1.3; 95% CI 1.0-1.8), whereas the two forms lacked major differences in the effect of parental eczema. A history of eczema in older siblings was a risk indicator for both forms of AD (OR 2.1; 95% CI 1.4-3.3 vs. OR 1.8; 95% CI 1.2-2.6). CONCLUSIONS: We found no difference between the effects of maternal and paternal atopic history. Parental eczema was a risk factor for AD irrespective of its association with IgE, but parental history of ARD mainly increased the risk of IgE-associated AD.
BACKGROUND: The aetiology of atopic dermatitis (AD) is presumably multi-factorial, with interactions between genetic and environmental factors. OBJECTIVE: To investigate the relation between atopic family history and development of AD up to 4 years. METHODS: Using annual questionnaires, we studied the cumulative incidence of AD in 0-4-year-olds in a prospective birth cohort of 4089. Atopic diseases in parents and siblings were recorded at birth. The occurrence of serum immunoglobulin E (IgE) antibodies to inhalant and food allergens was analysed in 2614 4-year-olds, and AD was divided into non-IgE-associated and IgE-associated. RESULTS: Of the children without atopic parents, 27.1% developed AD; of those with single or double parental atopic history, 37.9% and 50.0%, respectively, did so. The effects of parental history of eczema and of atopic respiratory disease (ARD) did not differ significantly, nor did those of maternal and paternal history. Parental history of ARD increased the risk significantly more for IgE-associated AD than for non-IgE-associated AD (odds ratio (OR) 2.0; 95% confidence interval (CI) 1.5-2.8 vs. OR 1.3; 95% CI 1.0-1.8), whereas the two forms lacked major differences in the effect of parental eczema. A history of eczema in older siblings was a risk indicator for both forms of AD (OR 2.1; 95% CI 1.4-3.3 vs. OR 1.8; 95% CI 1.2-2.6). CONCLUSIONS: We found no difference between the effects of maternal and paternal atopic history. Parental eczema was a risk factor for AD irrespective of its association with IgE, but parental history of ARD mainly increased the risk of IgE-associated AD.
Authors: Johannes Waage; Marie Standl; John A Curtin; Leon E Jessen; Jonathan Thorsen; Chao Tian; Nathan Schoettler; Carlos Flores; Abdel Abdellaoui; Tarunveer S Ahluwalia; Alexessander C Alves; Andre F S Amaral; Josep M Antó; Andreas Arnold; Amalia Barreto-Luis; Hansjörg Baurecht; Catharina E M van Beijsterveldt; Eugene R Bleecker; Sílvia Bonàs-Guarch; Dorret I Boomsma; Susanne Brix; Supinda Bunyavanich; Esteban G Burchard; Zhanghua Chen; Ivan Curjuric; Adnan Custovic; Herman T den Dekker; Shyamali C Dharmage; Julia Dmitrieva; Liesbeth Duijts; Markus J Ege; W James Gauderman; Michel Georges; Christian Gieger; Frank Gilliland; Raquel Granell; Hongsheng Gui; Torben Hansen; Joachim Heinrich; John Henderson; Natalia Hernandez-Pacheco; Patrick Holt; Medea Imboden; Vincent W V Jaddoe; Marjo-Riitta Jarvelin; Deborah L Jarvis; Kamilla K Jensen; Ingileif Jónsdóttir; Michael Kabesch; Jaakko Kaprio; Ashish Kumar; Young-Ae Lee; Albert M Levin; Xingnan Li; Fabian Lorenzo-Diaz; Erik Melén; Josep M Mercader; Deborah A Meyers; Rachel Myers; Dan L Nicolae; Ellen A Nohr; Teemu Palviainen; Lavinia Paternoster; Craig E Pennell; Göran Pershagen; Maria Pino-Yanes; Nicole M Probst-Hensch; Franz Rüschendorf; Angela Simpson; Kari Stefansson; Jordi Sunyer; Gardar Sveinbjornsson; Elisabeth Thiering; Philip J Thompson; Maties Torrent; David Torrents; Joyce Y Tung; Carol A Wang; Stephan Weidinger; Scott Weiss; Gonneke Willemsen; L Keoki Williams; Carole Ober; David A Hinds; Manuel A Ferreira; Hans Bisgaard; David P Strachan; Klaus Bønnelykke Journal: Nat Genet Date: 2018-07-16 Impact factor: 38.330
Authors: Sunna Thorsteinsdottir; Jakob Stokholm; Jacob P Thyssen; Sarah Nørgaard; Jonathan Thorsen; Bo L Chawes; Klaus Bønnelykke; Johannes Waage; Hans Bisgaard Journal: JAMA Dermatol Date: 2019-01-01 Impact factor: 10.282
Authors: Weiguo Yao; Florencia M Barbé-Tuana; Conrado J Llapur; Marcus H Jones; Christina Tiller; Risa Kimmel; Jeffrey Kisling; Evelyn T Nguyen; James Nguyen; Zhangsheng Yu; Mark H Kaplan; Robert S Tepper Journal: J Allergy Clin Immunol Date: 2010-09 Impact factor: 10.793
Authors: S Hasan Arshad; Wilfried Karmaus; Abid Raza; Ramesh J Kurukulaaratchy; Sharon M Matthews; John W Holloway; Alireza Sadeghnejad; Hongmei Zhang; Graham Roberts; Susan L Ewart Journal: J Allergy Clin Immunol Date: 2012-05-18 Impact factor: 10.793
Authors: Robert S Tepper; Conrado J Llapur; Marcus H Jones; Christina Tiller; Cathy Coates; Risa Kimmel; Jeffrey Kisling; Barry Katz; Yan Ding; Nancy Swigonski Journal: J Allergy Clin Immunol Date: 2008-08-28 Impact factor: 10.793