Literature DB >> 12955025

Effects of ageing on insulin secretion and action.

Niels Møller1, Lars Gormsen, Jens Fuglsang, Jakob Gjedsted.   

Abstract

One of the many conditions associated with ageing is type 2 diabetes mellitus, the prevalence of which increases from 20-30 years of age onwards. In many cases, type 2 diabetes mellitus is caused by the combination of insulin resistance and poor insulin secretion. Insulin resistance is also a risk factor associated with other disorders, in particular cardiovascular disease. Physiological changes associated with ageing, such as changes in body composition, decreased physical fitness, changes in hormones, and the secondary effects of high levels of free fatty acids and glucose, may also contribute to the impairment of insulin secretion and action. In this review, the effects of ageing on the secretion and action of insulin will be highlighted. Copyright 2003 S. Karger AG, Basel

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Year:  2003        PMID： 12955025     DOI： 10.1159/000071233

Source DB:  PubMed          Journal:  Horm Res        ISSN： 0301-0163


  14 in total

1.  Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.

Authors:  Jun Yoshino; Kathryn F Mills; Myeong Jin Yoon; Shin-ichiro Imai
Journal:  Cell Metab       Date:  2011-10-05       Impact factor: 27.287

Review 2.  Cardiovascular risk in aging and obesity: is there a role for GH.

Authors:  M Gola; S Bonadonna; M Doga; G Mazziotti; A Giustina
Journal:  J Endocrinol Invest       Date:  2005-09       Impact factor: 4.256

3.  Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence-accelerated prone male mice (SAMP8).

Authors:  Sara Cuesta; Roman Kireev; Cruz García; Lisa Rancan; Elena Vara; Jesús A F Tresguerres
Journal:  Age (Dordr)       Date:  2012-03-13

4.  Long-Term Change in both Dietary Insulinemic and Inflammatory Potential Is Associated with Weight Gain in Adult Women and Men.

Authors:  Fred K Tabung; Ambika Satija; Teresa T Fung; Steven K Clinton; Edward L Giovannucci
Journal:  J Nutr       Date:  2019-05-01       Impact factor: 4.798

5.  Cholesterol: from feeding to gene regulation.

Authors:  C Martini; V Pallottini
Journal:  Genes Nutr       Date:  2007-09-27       Impact factor: 5.523

6.  Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice.

Authors:  Kathryn Moynihan Ramsey; Kathryn F Mills; Akiko Satoh; Shin-Ichiro Imai
Journal:  Aging Cell       Date:  2007-11-14       Impact factor: 9.304

Review 7.  Endocrine alterations in response to calorie restriction in humans.

Authors:  Leanne M Redman; Eric Ravussin
Journal:  Mol Cell Endocrinol       Date:  2008-10-21       Impact factor: 4.102

Review 8.  Developmental and environmental epigenetic programming of the endocrine pancreas: consequences for type 2 diabetes.

Authors:  Ionel Sandovici; Constanze M Hammerle; Susan E Ozanne; Miguel Constância
Journal:  Cell Mol Life Sci       Date:  2013-03-06       Impact factor: 9.261

Review 9.  Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes.

Authors:  Shin-Ichiro Imai; Wieland Kiess
Journal:  Front Biosci (Landmark Ed)       Date:  2009-01-01

10.  Aging Reduces Insulin Clearance in Mice.

Authors:  Carine Marmentini; Gabriela M Soares; Gabriela A Bronczek; Silvano Piovan; Cecília E Mareze-Costa; Everardo M Carneiro; Antonio C Boschero; Mirian A Kurauti
Journal:  Front Endocrinol (Lausanne)       Date:  2021-05-12       Impact factor: 5.555
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