BACKGROUND: Of patients with superficial bladder cancer, a group are still at risk of disease recurrence, progression and death from their cancer after curative treatment. Angiogenesis is a crucial pathogenic mechanism for this type of urothelial cell carcinoma (UCC), and is a potential therapeutic target. However, the selection of the appropriate patients remains a dilemma. PATIENTS AND METHODS: Vascular endothelial growth factor (VEGF) expression and the presence of angiogenesis and occurrence of CD31, CD34, endoglin and factor VIII immunoexpression, were evaluated in 66 superficial papillary UCCs of the bladder and were correlated with classical histopathological factors and disease outcome. RESULTS: VEGF immunoreactivity was observed in 100% of cases, and more intensely in the luminal surface. The presence of microvessel clusters independently of a fibrovascular core was observed in 22.7% of cases. Of these, the T1/G2 subgroup had an independent and significantly lower recurrence-free survival (P = 0.0002). CONCLUSIONS: These results indicate that the presence of angiogenesis in tumour urothelium is a potential prognostic factor in superficial UCC, particularly in T1/G2 tumours, and may be used to select patients for anti-angiogenic treatments.
BACKGROUND: Of patients with superficial bladder cancer, a group are still at risk of disease recurrence, progression and death from their cancer after curative treatment. Angiogenesis is a crucial pathogenic mechanism for this type of urothelial cell carcinoma (UCC), and is a potential therapeutic target. However, the selection of the appropriate patients remains a dilemma. PATIENTS AND METHODS: Vascular endothelial growth factor (VEGF) expression and the presence of angiogenesis and occurrence of CD31, CD34, endoglin and factor VIII immunoexpression, were evaluated in 66 superficial papillary UCCs of the bladder and were correlated with classical histopathological factors and disease outcome. RESULTS:VEGF immunoreactivity was observed in 100% of cases, and more intensely in the luminal surface. The presence of microvessel clusters independently of a fibrovascular core was observed in 22.7% of cases. Of these, the T1/G2 subgroup had an independent and significantly lower recurrence-free survival (P = 0.0002). CONCLUSIONS: These results indicate that the presence of angiogenesis in tumour urothelium is a potential prognostic factor in superficial UCC, particularly in T1/G2 tumours, and may be used to select patients for anti-angiogenic treatments.
Authors: Farha A El-Chennawi; Fatma A Auf; Shereen S Metwally; Youssef M Mosaad; Atallah A Shaaban; Mahmoud Abdo El-Baz; Ziyad E Tawhid; Zakaria F Lotfy Journal: World J Gastrointest Oncol Date: 2009-10-15
Authors: Ji Eun Kwon; Nam Hoon Cho; Yeong-Jin Choi; So Dug Lim; Yong Mee Cho; Sun Young Jun; Sanghui Park; Young A Kim; Sung-Sun Kim; Mi Sun Choe; Jung-Dong Lee; Dae Yong Kang; Jae Y Ro; Hyun-Jung Kim Journal: Diagn Pathol Date: 2017-07-24 Impact factor: 2.644
Authors: Ekaterina Laukhtina; Victor M Schuettfort; David D'Andrea; Benjamin Pradere; Keiichiro Mori; Fahad Quhal; Reza Sari Motlagh; Hadi Mostafaei; Satoshi Katayama; Nico С Grossmann; Pawel Rajwa; Flora Zeinler; Mohammad Abufaraj; Marco Moschini; Kristin Zimmermann; Pierre I Karakiewicz; Harun Fajkovic; Douglas Scherr; Eva Compérat; Peter Nyirady; Michael Rink; Dmitry Enikeev; Shahrokh F Shariat Journal: Mol Carcinog Date: 2021-09-29 Impact factor: 5.139