Literature DB >> 12954077

Transcriptional regulation of methionine synthase by homocysteine and choline in Aspergillus nidulans.

Magdalena M Kacprzak1, Irmina Lewandowska, Rowena G Matthews, Andrzej Paszewski.   

Abstract

Roles played by homocysteine and choline in the regulation of MS (methionine synthase) have been examined in fungi. The Aspergillus nidulans metH gene encoding MS was cloned and characterized. Its transcription was not regulated by methionine, but was enhanced by homocysteine and repressed by choline and betaine. MS activity levels were regulated in a similar way. The repression by betaine was due to its metabolic conversion to choline, which was found to be very efficient in A. nidulans. Betaine and choline supplementation stimulated growth of leaky metH mutants apparently by decreasing the demand for methyl groups and thus saving methionine and S -adenosylmethionine. We have also found that homocysteine stimulates transcription of MS-encoding genes in Saccharomyces cerevisiae and Schizosaccharomyces pombe.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12954077      PMCID： PMC1223784          DOI： 10.1042/BJ20030747

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  36 in total

1.  Reduction of background problems in nonradioactive northern and Southern blot analyses enables higher sensitivity than 32P-based hybridizations.

Authors:  G Engler-Blum; M Meier; J Frank; G A Müller
Journal:  Anal Biochem       Date:  1993-05-01       Impact factor: 3.365

2.  Interactions of the Escherichia coli methionine repressor with the metF operator and with its corepressor, S-adenosylmethionine.

Authors:  I Saint-Girons; J Belfaiza; Y Guillou; D Perrin; N Guiso; O Bârzu; G N Cohen
Journal:  J Biol Chem       Date:  1986-08-15       Impact factor: 5.157

3.  The effect of homocysteine on MetR regulation of metE, metR and metH expression in vitro.

Authors:  X Y Cai; B Redfield; M Maxon; H Weissbach; N Brot
Journal:  Biochem Biophys Res Commun       Date:  1989-08-30       Impact factor: 3.575

4.  Deficiency in methionine adenosyltransferase resulting in limited repressibility of methionine biosynthetic enzymes in Aspergillus nidulans.

Authors:  N J Pieniazek; I M Kowalska; P P Stepień
Journal:  Mol Gen Genet       Date:  1973-11-22

5.  Methionine loci and their suppressors in Aspergillus nidulans.

Authors:  W Gajewski; J Litwińska
Journal:  Mol Gen Genet       Date:  1968

6.  Methionine methyl group metabolism in lemna.

Authors:  S H Mudd; A H Datko
Journal:  Plant Physiol       Date:  1986-05       Impact factor: 8.340

7.  Structure and regulation of cysD, the homocysteine synthase gene of Aspergillus nidulans.

Authors:  M Sieńko; J Topczewski; A Paszewski
Journal:  Curr Genet       Date:  1998-02       Impact factor: 3.886

8.  MET4, a leucine zipper protein, and centromere-binding factor 1 are both required for transcriptional activation of sulfur metabolism in Saccharomyces cerevisiae.

Authors:  D Thomas; I Jacquemin; Y Surdin-Kerjan
Journal:  Mol Cell Biol       Date:  1992-04       Impact factor: 4.272

9.  Regulation of folate-dependent enzyme levels in Aspergillus nidulans: studies with regulatory mutants.

Authors:  I Lewandowska; M Balińska; R Natorff; A Paszewski
Journal:  Biochim Biophys Acta       Date:  1996-05-21

10.  The general amino acid control regulates MET4, which encodes a methionine-pathway-specific transcriptional activator of Saccharomyces cerevisiae.

Authors:  H A Mountain; A S Byström; C Korch
Journal:  Mol Microbiol       Date:  1993-01       Impact factor: 3.501
View more
  16 in total

1.  Homocysteine- and cysteine-mediated growth defect is not associated with induction of oxidative stress response genes in yeast.

Authors:  Arun Kumar; Lijo John; Md Mahmood Alam; Ankit Gupta; Gayatri Sharma; Beena Pillai; Shantanu Sengupta
Journal:  Biochem J       Date:  2006-05-15       Impact factor: 3.857

2.  Interplay between Gliotoxin Resistance, Secretion, and the Methyl/Methionine Cycle in Aspergillus fumigatus.

Authors:  Rebecca A Owens; Grainne O'Keeffe; Elizabeth B Smith; Stephen K Dolan; Stephen Hammel; Kevin J Sheridan; David A Fitzpatrick; Thomas M Keane; Gary W Jones; Sean Doyle
Journal:  Eukaryot Cell       Date:  2015-07-06

3.  Methionine synthase is localized to the nucleus in Pichia pastoris and Candida albicans and to the cytoplasm in Saccharomyces cerevisiae.

Authors:  Umakant Sahu; Vinod K H Rajendra; Shankar S Kapnoor; Raghu Bhagavat; Nagasuma Chandra; Pundi N Rangarajan
Journal:  J Biol Chem       Date:  2017-07-12       Impact factor: 5.157

4.  Structure-guided function discovery of an NRPS-like glycine betaine reductase for choline biosynthesis in fungi.

Authors:  Yang Hai; Arthur M Huang; Yi Tang
Journal:  Proc Natl Acad Sci U S A       Date:  2019-05-06       Impact factor: 11.205

5.  Interrelations between glycine betaine catabolism and methionine biosynthesis in Sinorhizobium meliloti strain 102F34.

Authors:  Lise Barra; Catherine Fontenelle; Gwennola Ermel; Annie Trautwetter; Graham C Walker; Carlos Blanco
Journal:  J Bacteriol       Date:  2006-10       Impact factor: 3.490

6.  Exploration of Sulfur Assimilation of Aspergillus fumigatus Reveals Biosynthesis of Sulfur-Containing Amino Acids as a Virulence Determinant.

Authors:  Jorge Amich; Michaela Dümig; Gráinne O'Keeffe; Jasmin Binder; Sean Doyle; Andreas Beilhack; Sven Krappmann
Journal:  Infect Immun       Date:  2016-03-24       Impact factor: 3.441

Review 7.  The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species.

Authors:  Monika Schmoll; Christoph Dattenböck; Nohemí Carreras-Villaseñor; Artemio Mendoza-Mendoza; Doris Tisch; Mario Ivan Alemán; Scott E Baker; Christopher Brown; Mayte Guadalupe Cervantes-Badillo; José Cetz-Chel; Gema Rosa Cristobal-Mondragon; Luis Delaye; Edgardo Ulises Esquivel-Naranjo; Alexa Frischmann; Jose de Jesus Gallardo-Negrete; Monica García-Esquivel; Elida Yazmin Gomez-Rodriguez; David R Greenwood; Miguel Hernández-Oñate; Joanna S Kruszewska; Robert Lawry; Hector M Mora-Montes; Tania Muñoz-Centeno; Maria Fernanda Nieto-Jacobo; Guillermo Nogueira Lopez; Vianey Olmedo-Monfil; Macario Osorio-Concepcion; Sebastian Piłsyk; Kyle R Pomraning; Aroa Rodriguez-Iglesias; Maria Teresa Rosales-Saavedra; J Alejandro Sánchez-Arreguín; Verena Seidl-Seiboth; Alison Stewart; Edith Elena Uresti-Rivera; Chih-Li Wang; Ting-Fang Wang; Susanne Zeilinger; Sergio Casas-Flores; Alfredo Herrera-Estrella
Journal:  Microbiol Mol Biol Rev       Date:  2016-02-10       Impact factor: 11.056

8.  Accumulation of homolanthionine and activation of a novel pathway for isoleucine biosynthesis in Corynebacterium glutamicum McbR deletion strains.

Authors:  Jens Olaf Krömer; Elmar Heinzle; Hartwig Schröder; Christoph Wittmann
Journal:  J Bacteriol       Date:  2006-01       Impact factor: 3.490

9.  Serine O-acetyltransferase is important, but not essential for cysteine-methionine synthesis in Fusarium graminearum.

Authors:  Jing Fu; Xiaoping Zhang; Xiang Chen; Yanni Yin; Zhonghua Ma
Journal:  World J Microbiol Biotechnol       Date:  2013-11-06       Impact factor: 3.312

10.  Aspergillus nidulans genes encoding reverse transsulfuration enzymes belong to homocysteine regulon.

Authors:  Marzena Sieńko; Renata Natorff; Sylwia Owczarek; Igor Olewiecki; Andrzej Paszewski
Journal:  Curr Genet       Date:  2009-08-15       Impact factor: 3.886
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.