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Literature DB >> 2673243

The effect of homocysteine on MetR regulation of metE, metR and metH expression in vitro.

X Y Cai¹, B Redfield, M Maxon, H Weissbach, N Brot.

Abstract

An Escherichia coli S-30 DNA directed protein synthesis system was used to study the effect of homocysteine on the in vitro expression of the metE, metH and metR genes. In the presence of purified MetR protein, which is known to regulate the expression of these genes, homocysteine activates metE expression and inhibits both metR and metH expression. These findings support the recent in vivo results of Urbanowski, M.L. and Stauffer, G.V. (1989), J. Bacteriol. 171, 3277-3281.

Entities: Chemical Gene Species

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Year: 1989 PMID： 2673243 DOI： 10.1016/0006-291x(89)92101-3

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

12 in total

1. Role of the MetR regulatory system in vitamin B12-mediated repression of the Salmonella typhimurium metE gene.

Authors: W F Wu; M L Urbanowski; G V Stauffer
Journal: J Bacteriol Date: 1992-07 Impact factor: 3.490

2. Structure-function studies on Escherichia coli MetR protein, a putative prokaryotic leucine zipper protein.

Authors: M E Maxon; J Wigboldus; N Brot; H Weissbach
Journal: Proc Natl Acad Sci U S A Date: 1990-09 Impact factor: 11.205

3. luxS-dependent gene regulation in Escherichia coli K-12 revealed by genomic expression profiling.

Authors: Liang Wang; Jun Li; John C March; James J Valdes; William E Bentley
Journal: J Bacteriol Date: 2005-12 Impact factor: 3.490

4. Regulation of the Salmonella typhimurium metA gene by the metR protein and homocysteine.

Authors: R Mares; M L Urbanowski; G V Stauffer
Journal: J Bacteriol Date: 1992-01 Impact factor: 3.490

5. At least four regulatory genes control sulphur metabolite repression in Aspergillus nidulans.

Authors: R Natorff; M Balińska; A Paszewski
Journal: Mol Gen Genet Date: 1993-04

6. A mutation in the rpoA gene encoding the alpha subunit of RNA polymerase that affects metE-metR transcription in Escherichia coli.

Authors: S Jafri; M L Urbanowski; G V Stauffer
Journal: J Bacteriol Date: 1995-02 Impact factor: 3.490

The effect of homocysteine on MetR regulation of metE, metR and metH expression in vitro.

1. Role of the MetR regulatory system in vitamin B12-mediated repression of the Salmonella typhimurium metE gene.

2. Structure-function studies on Escherichia coli MetR protein, a putative prokaryotic leucine zipper protein.

3. luxS-dependent gene regulation in Escherichia coli K-12 revealed by genomic expression profiling.

4. Regulation of the Salmonella typhimurium metA gene by the metR protein and homocysteine.

5. At least four regulatory genes control sulphur metabolite repression in Aspergillus nidulans.

6. A mutation in the rpoA gene encoding the alpha subunit of RNA polymerase that affects metE-metR transcription in Escherichia coli.

7. Characterization of a second MetR-binding site in the metE metR regulatory region of Salmonella typhimurium.

8. Sulfur amino acid metabolism and its control in Lactococcus lactis IL1403.

9. The Salmonella typhimurium virulence plasmid encodes a positive regulator of a plasmid-encoded virulence gene.

10. The metR binding site in the Salmonella typhimurium metH gene: DNA sequence constraints on activation.