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Literature DB >> 12951123

Muraymycins, novel peptidoglycan biosynthesis inhibitors: synthesis and SAR of their analogues.

Ayako Yamashita¹, Emily Norton, Peter J Petersen, Beth A Rasmussen, Guy Singh, Youjin Yang, Tarek S Mansour, Douglas M Ho.

Abstract

A series of Muraymycin analogues was synthesized. These analogues showed excellent antimicrobial activity against gram-positive organisms. These analogues also showed excellent inhibitory activity against the target peptidoglycan biosynthesis enzyme MraY, the cell membrane associated transglycosylase responsible for the formation of Lipid II.

Entities: Chemical

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Year: 2003 PMID： 12951123 DOI： 10.1016/s0960-894x(03)00671-1

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

18 in total

Review 1. A comprehensive review of glycosylated bacterial natural products.

Authors: Sherif I Elshahawi; Khaled A Shaaban; Madan K Kharel; Jon S Thorson
Journal: Chem Soc Rev Date: 2015-11-07 Impact factor: 54.564

2. Insights into the Target Interaction of Naturally Occurring Muraymycin Nucleoside Antibiotics.

Authors: Stefan Koppermann; Zheng Cui; Patrick D Fischer; Xiachang Wang; Jannine Ludwig; Jon S Thorson; Steven G Van Lanen; Christian Ducho
Journal: ChemMedChem Date: 2018-03-23 Impact factor: 3.466

3. Synthesis and Biological Evaluation of Muraymycin Analogues Active against Anti-Drug-Resistant Bacteria.

Authors: Tetsuya Tanino; Satoshi Ichikawa; Bayan Al-Dabbagh; Ahmed Bouhss; Hiroshi Oyama; Akira Matsuda
Journal: ACS Med Chem Lett Date: 2010-06-02 Impact factor: 4.345

4. Fluorescence-based assay for polyprenyl phosphate-GlcNAc-1-phosphate transferase (WecA) and identification of novel antimycobacterial WecA inhibitors.

Authors: Katsuhiko Mitachi; Shajila Siricilla; Dong Yang; Ying Kong; Karolina Skorupinska-Tudek; Ewa Swiezewska; Scott G Franzblau; Michio Kurosu
Journal: Anal Biochem Date: 2016-08-13 Impact factor: 3.365

Muraymycins, novel peptidoglycan biosynthesis inhibitors: synthesis and SAR of their analogues.

Review 1. A comprehensive review of glycosylated bacterial natural products.

2. Insights into the Target Interaction of Naturally Occurring Muraymycin Nucleoside Antibiotics.

3. Synthesis and Biological Evaluation of Muraymycin Analogues Active against Anti-Drug-Resistant Bacteria.

4. Fluorescence-based assay for polyprenyl phosphate-GlcNAc-1-phosphate transferase (WecA) and identification of novel antimycobacterial WecA inhibitors.

5. Synthesis of ureidomuraymycidine derivatives for structure-activity relationship studies of muraymycins.

6. A reliable Pd-mediated hydrogenolytic deprotection of BOM group of uridine ureido nitrogen.

7. Biosynthesis of a water-soluble lipid I analogue and a convenient assay for translocase I.

8. Stereocontrolled Total Synthesis of Muraymycin D1 Having a Dual Mode of Action against Mycobacterium tuberculosis.

Review 9. Structures of Bacterial MraY and Human GPT Provide Insights into Rational Antibiotic Design.

10. A Modular Approach to Phosphoglycosyltransferase Inhibitors Inspired by Nucleoside Antibiotics.