| Literature DB >> 12950898 |
H C Gugnani1, K Becker, W Fegeler, S Basu, D Chattopadhya, U Baveja, S Satyanarayana, T Kalghatgi, A Murlidhar.
Abstract
The present investigation represents the first study of oropharyngeal carriage of Candida and other yeasts in HIV-infected patients in India. One hundred and fifty HIV-positive patients were investigated by culturing their swish samples on plates of CHROMagar Candida. Ninety-eight patients (65.3%) were positive for Candida and four (2.7%) were positive for other yeasts. Among them, the first Indian C. dubliniensis isolate has been recovered. Molecular typing of selected C. albicans isolates by AP-PCR revealed two major genotypes based on the banding patterns. The susceptibilities of 30 Candida isolates to five antifungal agents including the new triazole voriconazole were determined in a micro-dilution test, according to the NCCLS protocol M 27. All the 22 C. albicans isolates were susceptible to five antimycotic agents (flucytosine, amphotericin B, fluconazole, voriconazole and itraconazole) except one isolate (VPCI-122), which was resistant to flucytosine (MIC > or = 64 mg l-1). The azole-resistant isolates reported here endorse the role of antifungal susceptibility testing whenever antifungal treatment with azoles is planned.Entities:
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Year: 2003 PMID： 12950898 DOI： 10.1046/j.1439-0507.2003.00896.x
Source DB: PubMed Journal: Mycoses ISSN： 0933-7407 Impact factor: 4.377