| Literature DB >> 12950711 |
Maher Karam-Hage1, Kirk J Brower.
Abstract
Alcohol-dependent outpatients with persisting insomnia were treated with either gabapentin or trazodone. Patients were assessed at baseline and after 4-6 weeks on medication using the Sleep Problems Questionnaire (SPQ). Of 55 cases initially treated, 9% dropped out due to morning drowsiness. Of the remaining 50 cases, 34 were treated with gabapentin (mean dose +/- SD = 888 +/- 418 mg) at bedtime and 16 were treated with trazodone (105 +/- 57 mg) at bedtime. Both groups improved significantly on the SPQ but the gabapentin group improved significantly more than the trazodone group. Controlled studies are warranted to replicate these findings.Entities:
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Year: 2003 PMID： 12950711 PMCID： PMC2967491 DOI： 10.1046/j.1440-1819.2003.01161.x
Source DB: PubMed Journal: Psychiatry Clin Neurosci ISSN： 1323-1316 Impact factor: 5.188