Literature DB >> 12948782

Designing proteins for therapeutic applications.

Greg A Lazar1, Shannon A Marshall, Joseph J Plecs, Stephen L Mayo, John R Desjarlais.   

Abstract

Protein design is becoming an increasingly useful tool for optimizing protein drugs and creating novel biotherapeutics. Recent progress includes the engineering of monoclonal antibodies, cytokines, enzymes and viral fusion inhibitors.

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Year:  2003        PMID： 12948782     DOI： 10.1016/s0959-440x(03)00104-0

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN： 0959-440X            Impact factor:   6.809


  18 in total

1.  Distance-dependent statistical potentials for discriminating thermophilic and mesophilic proteins.

Authors:  Yunqi Li; Jianwen Fang
Journal:  Biochem Biophys Res Commun       Date:  2010-05-06       Impact factor: 3.575

2.  Computational protein design is a challenge for implicit solvation models.

Authors:  Alfonso Jaramillo; Shoshana J Wodak
Journal:  Biophys J       Date:  2004-09-17       Impact factor: 4.033

3.  Structural insights into conformational stability of wild-type and mutant beta1-adrenergic receptor.

Authors:  Gouthaman S Balaraman; Supriyo Bhattacharya; Nagarajan Vaidehi
Journal:  Biophys J       Date:  2010-07-21       Impact factor: 4.033

4.  Chimeric glutathione S-transferases containing inserts of kininogen peptides: potential novel protein therapeutics.

Authors:  Amber A Bentley; Sergei M Merkulov; Yi Peng; Rita Rozmarynowycz; Xiaoping Qi; Marianne Pusztai-Carey; William C Merrick; Vivien C Yee; Keith R McCrae; Anton A Komar
Journal:  J Biol Chem       Date:  2012-05-10       Impact factor: 5.157

Review 5.  Glycosylation of therapeutic proteins: an effective strategy to optimize efficacy.

Authors:  Ricardo J Solá; Kai Griebenow
Journal:  BioDrugs       Date:  2010-02-01       Impact factor: 5.807

6.  A critical review of five machine learning-based algorithms for predicting protein stability changes upon mutation.

Authors:  Jianwen Fang
Journal:  Brief Bioinform       Date:  2020-07-15       Impact factor: 11.622

7.  Cis-suppression to arrest protein aggregation in mammalian cells.

Authors:  Simpson Gregoire; Shaojie Zhang; Joseph Costanzo; Kelly Wilson; Erik J Fernandez; Inchan Kwon
Journal:  Biotechnol Bioeng       Date:  2013-10-18       Impact factor: 4.530

8.  Increasing protein stability by improving beta-turns.

Authors:  Hailong Fu; Gerald R Grimsley; Abbas Razvi; J Martin Scholtz; C Nick Pace
Journal:  Proteins       Date:  2009-11-15

9.  Computational design of receptors for an organophosphate surrogate of the nerve agent soman.

Authors:  Malin Allert; Shahir S Rizk; Loren L Looger; Homme W Hellinga
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-17       Impact factor: 11.205

10.  A computational framework to empower probabilistic protein design.

Authors:  Menachem Fromer; Chen Yanover
Journal:  Bioinformatics       Date:  2008-07-01       Impact factor: 6.937
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