| Literature DB >> 1294700 |
C K Angerhofer1, J M Pezzuto, G M König, A D Wright, O Sticher.
Abstract
Five sesquiterpenoids containing isonitrile or isothiocyanate groups were isolated from the sponge Acanthella klethra. Compounds 1 and 2 were identified as axisonitrile 3 and the corresponding isothiocyanate derivative, respectively. Compounds 3-5 were found to be eudesmane sesquiterpenes. None of these compounds was cytotoxic toward cultured KB-3 cells, but varying degrees of activity were observed with cultured Plasmodium falciparum. Compound 1 demonstrated greatest promise as an antimalarial agent.Entities:
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Year: 1992 PMID： 1294700 DOI： 10.1021/np50090a014
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050