Literature DB >> 12945738

Loading amplification of radiation grafted polymers (crowns and lanterns) and their application in the solid-phase synthesis of hydantoin libraries.

Sylvain Lebreton1, Nicholas Newcombe, Mark Bradley.   

Abstract

Solid-phase dendrimer chemistry using a symmetrical 1 --> 3 C-branched isocyanate monomer was used to prepare radiation-grafted polymers with enhanced loading. After evaluation of the physical and chemical properties of these new high-loading supports, they were tested in the multiple parallel synthesis of hydantoins.

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Year:  2003        PMID： 12945738     DOI： 10.1023/a:1024867013184

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  17 in total

1.  Solid-phase combinatorial synthesis using MicroKan reactors, Rf tagging, and directed sorting.

Authors:  X Y Xiao; R Li; H Zhuang; B Ewing; K Karunaratne; J Lillig; R Brown; K C Nicolaou
Journal:  Biotechnol Bioeng       Date:  2000       Impact factor: 4.530

2.  Revolutionizing Resin Handling for Combinatorial Synthesis.

Authors:  Butrus Atrash; Mark Bradley; Ryzard Kobylecki; Dan Cowell; John Reader
Journal:  Angew Chem Int Ed Engl       Date:  2001-03-02       Impact factor: 15.336

3.  The "One-Bead-One-Compound" Combinatorial Library Method.

Authors:  Kit S. Lam; Michal Lebl; Viktor Krchnák
Journal:  Chem Rev       Date:  1997-04-01       Impact factor: 60.622

4.  General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

Authors:  R A Houghten
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

Review 5.  Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids.

Authors:  G B Fields; R L Noble
Journal:  Int J Pept Protein Res       Date:  1990-03

Review 6.  Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries.

Authors:  M A Gallop; R W Barrett; W J Dower; S P Fodor; E M Gordon
Journal:  J Med Chem       Date:  1994-04-29       Impact factor: 7.446

7.  "Diversomers": an approach to nonpeptide, nonoligomeric chemical diversity.

Authors:  S H DeWitt; J S Kiely; C J Stankovic; M C Schroeder; D M Cody; M R Pavia
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-01       Impact factor: 11.205

8.  Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.

Authors:  H M Geysen; R H Meloen; S J Barteling
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205

9.  Quantitative monitoring of solid-phase peptide synthesis by the ninhydrin reaction.

Authors:  V K Sarin; S B Kent; J P Tam; R B Merrifield
Journal:  Anal Biochem       Date:  1981-10       Impact factor: 3.365
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