Literature DB >> 12941427

The completed human genome: implications for chemical biology.

Christopher P Austin1.   

Abstract

The recently completed human genome sequence represents an enormous opportunity to understand biology and accelerate the development of new therapeutics. However, it also presents equally large logistical, scientific and paradigmatic challenges to efficiently translate the enormous cache of sequence data into functional information that will be the precursor of new drug development. Small-molecule chemical biology applied on a genomic scale promises to speed this translation to novel therapeutics.

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Year:  2003        PMID: 12941427     DOI: 10.1016/s1367-5931(03)00083-8

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN: 1367-5931            Impact factor:   8.822


  8 in total

1.  Postgenomic chemical biology.

Authors: 
Journal:  Nat Chem Biol       Date:  2010-09       Impact factor: 15.040

Review 2.  A cheminformatic toolkit for mining biomedical knowledge.

Authors:  Gus R Rosania; Gordon Crippen; Peter Woolf; David States; Kerby Shedden
Journal:  Pharm Res       Date:  2007-03-24       Impact factor: 4.200

3.  Synthesis of a unique isoindoline/tetrahydroisoquinoline-based tricyclic sultam library utilizing a Heck-aza-Michael strategy.

Authors:  Qin Zang; Salim Javed; Patrick Porubsky; Farman Ullah; Benjamin Neuenswander; Gerald H Lushington; Fatima Z Basha; Michael G Organ; Paul R Hanson
Journal:  ACS Comb Sci       Date:  2012-02-06       Impact factor: 3.784

Review 4.  Impact of high-throughput screening in biomedical research.

Authors:  Ricardo Macarron; Martyn N Banks; Dejan Bojanic; David J Burns; Dragan A Cirovic; Tina Garyantes; Darren V S Green; Robert P Hertzberg; William P Janzen; Jeff W Paslay; Ulrich Schopfer; G Sitta Sittampalam
Journal:  Nat Rev Drug Discov       Date:  2011-03       Impact factor: 84.694

5.  Application of a Double Aza-Michael Reaction in a 'Click, Click, Cy-Click' Strategy: From Bench to Flow.

Authors:  Qin Zang; Salim Javed; Farman Ullah; Aihua Zhou; Christopher A Knudtson; Danse Bi; Fatima Z Basha; Michael G Organ; Paul R Hanson
Journal:  Synthesis (Stuttg)       Date:  2011-09-01       Impact factor: 3.157

6.  Reagent based DOS: a "Click, Click, Cyclize" strategy to probe chemical space.

Authors:  Alan Rolfe; Gerald H Lushington; Paul R Hanson
Journal:  Org Biomol Chem       Date:  2010-03-16       Impact factor: 3.876

Review 7.  Probing the probes: fitness factors for small molecule tools.

Authors:  Paul Workman; Ian Collins
Journal:  Chem Biol       Date:  2010-06-25

Review 8.  Natural Products as Modulators of Sirtuins.

Authors:  Berin Karaman Mayack; Wolfgang Sippl; Fidele Ntie-Kang
Journal:  Molecules       Date:  2020-07-20       Impact factor: 4.411

  8 in total

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