| Literature DB >> 12938207 |
Sandra Frabasile1, Adriana Delfraro, Luján Facal, Cristina Videla, Mónica Galiano, María José de Sierra, Dora Ruchansky, Nathalia Vitureira, Mabel Berois, Guadalupe Carballal, José Russi, Juan Arbiza.
Abstract
The antigenic and genetic diversity of G glycoprotein from 25 human respiratory viruses (group A) isolated during nine consecutive epidemics (1993-2001) in Montevideo, Uruguay, and 7 strains isolated in Buenos Aires, Argentina, in the same period were analyzed. Genetic variability was evaluated by partial sequence of the G protein gene. Phylogenetic analysis indicated that most Uruguayan and Argentinean group A isolates clustered into three genotypes: GA5, GA2, and GA1. Some strains clustered into the GA3 genotype characterized previously. The antigenic analysis was carried out with a panel of anti-G monoclonal antibodies that recognized conserved and strain-specific epitopes. A close correlation between the antigenic and genetic relatedness of the strains analyzed was observed. Copyright 2003 Wiley-Liss, Inc.Entities:
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Year: 2003 PMID: 12938207 DOI: 10.1002/jmv.10484
Source DB: PubMed Journal: J Med Virol ISSN: 0146-6615 Impact factor: 2.327