Literature DB >> 12937969

Fosmidomycin for the treatment of malaria.

Jochen Wiesner1, Steffen Borrmann, Hassan Jomaa.   

Abstract

In malaria parasites, isoprenoids are synthesised by the mevalonate independent 1-deoxy- D-xylulose 5-phosphate (DOXP) pathway. Fosmidomycin, a natural antibiotic originally developed for the treatment of bacterial infections, represents an inhibitor of DOXP reductoisomerase, an essential enzyme of this pathway. In recent clinical studies it was shown that fosmidomycin is effective in curing uncomplicated Plasmodium falciparum malaria in humans. The treatment was well tolerated and resulted in a fast parasite and fever clearance. However, the high rate of recrudescence precludes the use of fosmidomycin as a monotherapy. In drug combination studies, synergy of fosmidomycin with clindamycin was observed. Clinical studies with a fosmidomycin-clindamycin combination are currently ongoing.

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Year:  2002        PMID： 12937969     DOI： 10.1007/s00436-002-0770-9

Source DB:  PubMed          Journal:  Parasitol Res        ISSN： 0932-0113            Impact factor:   2.289


  36 in total

Review 1.  The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plants.

Authors:  M Rohmer
Journal:  Nat Prod Rep       Date:  1999-10       Impact factor: 13.423

2.  Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase complexed with cofactors: implications of a flexible loop movement upon substrate binding.

Authors:  Shunsuke Yajima; Takamasa Nonaka; Tomohisa Kuzuyama; Haruo Seto; Kanju Ohsawa
Journal:  J Biochem       Date:  2002-03       Impact factor: 3.387

3.  Diaryl ester prodrugs of FR900098 with improved in vivo antimalarial activity.

Authors:  A Reichenberg; J Wiesner; C Weidemeyer; E Dreiseidler; S Sanderbrand; B Altincicek; E Beck; M Schlitzer; H Jomaa
Journal:  Bioorg Med Chem Lett       Date:  2001-03-26       Impact factor: 2.823

4.  GcpE is involved in the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli.

Authors:  B Altincicek; A K Kollas; S Sanderbrand; J Wiesner; M Hintz; E Beck; H Jomaa
Journal:  J Bacteriol       Date:  2001-04       Impact factor: 3.490

5.  LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli.

Authors:  B Altincicek; A Kollas; M Eberl; J Wiesner; S Sanderbrand; M Hintz; E Beck; H Jomaa
Journal:  FEBS Lett       Date:  2001-06-15       Impact factor: 4.124

6.  Biosynthesis of ubiquinones by malarial parasites. I. Isolation of [14C]ubiquinones from cultures of rhesus monkey blood infected with Plasmodium knowlesi.

Authors:  F S Skelton; K D Lunan; K Folkers; J V Schnell; W A Siddiqui; Q M Geiman
Journal:  Biochemistry       Date:  1969-03       Impact factor: 3.162

7.  Active isoprenoid pathway in the intra-erythrocytic stages of Plasmodium falciparum: presence of dolichols of 11 and 12 isoprene units.

Authors:  A S Couto; E A Kimura; V J Peres; M L Uhrig; A M Katzin
Journal:  Biochem J       Date:  1999-08-01       Impact factor: 3.857

8.  Biosynthesis of terpenoids. 2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) from Plasmodium falciparum.

Authors:  F Rohdich; W Eisenreich; J Wungsintaweekul; S Hecht; C A Schuhr; A Bacher
Journal:  Eur J Biochem       Date:  2001-06

9.  Pharmacokinetics and metabolism of fosmidomycin, a new phosphonic acid, in rats and dogs.

Authors:  T Tsuchiya; K Ishibashi; M Terakawa; M Nishiyama; N Itoh; H Noguchi
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1982 Jan-Mar       Impact factor: 2.441

10.  Studies on new phosphonic acid antibiotics. III. Isolation and characterization of FR-31564, FR-32863 and FR-33289.

Authors:  M Okuhara; Y Kuroda; T Goto; M Okamoto; H Terano; M Kohsaka; H Aoki; H Imanaka
Journal:  J Antibiot (Tokyo)       Date:  1980-01       Impact factor: 2.649
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  34 in total

1.  A chemical rescue screen identifies a Plasmodium falciparum apicoplast inhibitor targeting MEP isoprenoid precursor biosynthesis.

Authors:  Wesley Wu; Zachary Herrera; Danny Ebert; Katie Baska; Seok H Cho; Joseph L DeRisi; Ellen Yeh
Journal:  Antimicrob Agents Chemother       Date:  2014-11-03       Impact factor: 5.191

2.  Superessential reactions in metabolic networks.

Authors:  Aditya Barve; João Frederico Matias Rodrigues; Andreas Wagner
Journal:  Proc Natl Acad Sci U S A       Date:  2012-04-16       Impact factor: 11.205

3.  Randomized controlled trial of fosmidomycin-clindamycin versus sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria.

Authors:  Sunny Oyakhirome; Saadou Issifou; Peter Pongratz; Fortune Barondi; Michael Ramharter; Jürgen F Kun; Michel A Missinou; Bertrand Lell; Peter G Kremsner
Journal:  Antimicrob Agents Chemother       Date:  2007-02-26       Impact factor: 5.191

4.  Plastid isoprenoid metabolism in the oyster parasite Perkinsus marinus connects dinoflagellates and malaria pathogens--new impetus for studying alveolates.

Authors:  Carina Grauvogel; Kimberly S Reece; Henner Brinkmann; Jörn Petersen
Journal:  J Mol Evol       Date:  2007-11-27       Impact factor: 2.395

5.  Fosmidomycin plus clindamycin for treatment of pediatric patients aged 1 to 14 years with Plasmodium falciparum malaria.

Authors:  Steffen Borrmann; Ingrid Lundgren; Sunny Oyakhirome; Bénido Impouma; Pierre-Blaise Matsiegui; Ayola A Adegnika; Saadou Issifou; Jürgen F J Kun; David Hutchinson; Jochen Wiesner; Hassan Jomaa; Peter G Kremsner
Journal:  Antimicrob Agents Chemother       Date:  2006-08       Impact factor: 5.191

6.  Inadequate efficacy of a new formulation of fosmidomycin-clindamycin combination in Mozambican children less than three years old with uncomplicated Plasmodium falciparum malaria.

Authors:  Miguel Lanaspa; Cinta Moraleda; Sónia Machevo; Raquel González; Beatriz Serrano; Eusebio Macete; Pau Cisteró; Alfredo Mayor; David Hutchinson; Peter G Kremsner; Pedro Alonso; Clara Menéndez; Quique Bassat
Journal:  Antimicrob Agents Chemother       Date:  2012-03-19       Impact factor: 5.191

7.  New N-acetyltransferase fold in the structure and mechanism of the phosphonate biosynthetic enzyme FrbF.

Authors:  Brian Bae; Ryan E Cobb; Matthew A DeSieno; Huimin Zhao; Satish K Nair
Journal:  J Biol Chem       Date:  2011-08-24       Impact factor: 5.157

Review 8.  Biochemistry of the non-mevalonate isoprenoid pathway.

Authors:  Tobias Gräwert; Michael Groll; Felix Rohdich; Adelbert Bacher; Wolfgang Eisenreich
Journal:  Cell Mol Life Sci       Date:  2011-07-09       Impact factor: 9.261

9.  Mycoplasma penetrans is capable of activating V gamma 9/V delta 2 T cells while other human pathogenic mycoplasmas fail to do so.

Authors:  Matthias Eberl; Martin Hintz; Zandraa Jamba; Ewald Beck; Hassan Jomaa; Gunna Christiansen
Journal:  Infect Immun       Date:  2004-08       Impact factor: 3.441

10.  Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase.

Authors:  Lionel Kuntz; Denis Tritsch; Catherine Grosdemange-Billiard; Andréa Hemmerlin; Audrey Willem; Thomas J Bach; Michel Rohmer
Journal:  Biochem J       Date:  2005-02-15       Impact factor: 3.857
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