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Literature DB >> 12933896

Signaling via Toll-like receptor 5 can initiate inflammatory mediator production by murine osteoblasts.

Denise R Madrazo¹, Susanne L Tranguch, Ian Marriott.

Abstract

Murine osteoblasts express Toll-like receptor 5 (TLR5), and this expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Importantly, flagellin activates transcriptional regulators and elicits proinflammatory cytokine production, suggesting TLR5 functionality. TLR5 may represent an important mechanism underlying the recognition of bacterial pathogens by osteoblasts during bone infections.

Entities: Disease Gene Species

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Year: 2003 PMID： 12933896 PMCID： PMC187346 DOI： 10.1128/IAI.71.9.5418-5421.2003

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

24 in total

1. A Toll-like receptor recognizes bacterial DNA.

Authors: H Hemmi; O Takeuchi; T Kawai; T Kaisho; S Sato; H Sanjo; M Matsumoto; K Hoshino; H Wagner; K Takeda; S Akira
Journal: Nature Date: 2000-12-07 Impact factor: 49.962

Review 2. The Toll receptor family and microbial recognition.

Authors: R Medzhitov; C Janeway
Journal: Trends Microbiol Date: 2000-10 Impact factor: 17.079

3. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5.

Authors: F Hayashi; K D Smith; A Ozinsky; T R Hawn; E C Yi; D R Goodlett; J K Eng; S Akira; D M Underhill; A Aderem
Journal: Nature Date: 2001-04-26 Impact factor: 49.962

4. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide.

Authors: E Lien; T K Means; H Heine; A Yoshimura; S Kusumoto; K Fukase; M J Fenton; M Oikawa; N Qureshi; B Monks; R W Finberg; R R Ingalls; D T Golenbock
Journal: J Clin Invest Date: 2000-02 Impact factor: 14.808

5. Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors.

Authors: T Kikuchi; T Matsuguchi; N Tsuboi; A Mitani; S Tanaka; M Matsuoka; G Yamamoto; T Hishikawa; T Noguchi; Y Yoshikai
Journal: J Immunol Date: 2001-03-01 Impact factor: 5.422

6. Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2.

Authors: A Yoshimura; E Lien; R R Ingalls; E Tuomanen; R Dziarski; D Golenbock
Journal: J Immunol Date: 1999-07-01 Impact factor: 5.422

7. Staphylococcus aureus infection of mouse or human osteoblasts induces high levels of interleukin-6 and interleukin-12 production.

Authors: K L Bost; W K Ramp; N C Nicholson; J L Bento; I Marriott; M C Hudson
Journal: J Infect Dis Date: 1999-12 Impact factor: 5.226

8. Induction of colony-stimulating factor expression following Staphylococcus or Salmonella interaction with mouse or human osteoblasts.

Authors: K L Bost; J L Bento; J K Ellington; I Marriott; M C Hudson
Journal: Infect Immun Date: 2000-09 Impact factor: 3.441

9. Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice.

Authors: G Sebastiani; G Leveque; L Larivière; L Laroche; E Skamene; P Gros; D Malo
Journal: Genomics Date: 2000-03-15 Impact factor: 5.736

10. IL-4 and IFN-gamma up-regulate substance P receptor expression in murine peritoneal macrophages.

Authors: I Marriott; K L Bost
Journal: J Immunol Date: 2000-07-01 Impact factor: 5.422

11 in total

1. Flagellin fusion proteins as adjuvants or vaccines induce specific immune responses.

Authors: Camilo Cuadros; Francisco J Lopez-Hernandez; Ana Lucia Dominguez; Michael McClelland; Joseph Lustgarten
Journal: Infect Immun Date: 2004-05 Impact factor: 3.441

Review 2. Osteoblast responses to bacterial pathogens: a previously unappreciated role for bone-forming cells in host defense and disease progression.

Authors: Ian Marriott
Journal: Immunol Res Date: 2004 Impact factor: 2.829

3. Induction of Nod1 and Nod2 intracellular pattern recognition receptors in murine osteoblasts following bacterial challenge.

Authors: Ian Marriott; Dana M Rati; Samuel H McCall; Susanne L Tranguch
Journal: Infect Immun Date: 2005-05 Impact factor: 3.441

Review 4. Effects of flagellin on innate and adaptive immunity.

Authors: Anna N Honko; Steven B Mizel
Journal: Immunol Res Date: 2005 Impact factor: 2.829

5. A bacterial flagellin, Vibrio vulnificus FlaB, has a strong mucosal adjuvant activity to induce protective immunity.

Authors: Shee Eun Lee; Soo Young Kim; Byung Chul Jeong; Young Ran Kim; Soo Jang Bae; Ouk Seon Ahn; Je-Jung Lee; Ho-Chun Song; Jung Mogg Kim; Hyon E Choy; Sun Sik Chung; Mi-Na Kweon; Joon Haeng Rhee
Journal: Infect Immun Date: 2006-01 Impact factor: 3.441

Review 6. Pathogen-host interactions in Pseudomonas aeruginosa pneumonia.

Authors: Ruxana T Sadikot; Timothy S Blackwell; John W Christman; Alice S Prince
Journal: Am J Respir Crit Care Med Date: 2005-02-01 Impact factor: 21.405

7. Osteoblasts express NLRP3, a nucleotide-binding domain and leucine-rich repeat region containing receptor implicated in bacterially induced cell death.

Authors: Samuel H McCall; Mahnaz Sahraei; Amy B Young; Charles S Worley; Joseph A Duncan; Jenny Pan-Yun Ting; Ian Marriott
Journal: J Bone Miner Res Date: 2008-01 Impact factor: 6.741