Literature DB >> 12933892

Nicotinamide ribosyl uptake mutants in Haemophilus influenzae.

Mark Herbert1, Elizabeta Sauer, Graeme Smethurst, Anita Kraiss, Anna-Karina Hilpert, Joachim Reidl.   

Abstract

The gene for the nicotinamide riboside (NR) transporter (pnuC) was identified in Haemophilus influenzae. A pnuC mutant had only residual NR uptake and could survive in vitro with high concentrations of NR, but could not survive in vivo. PnuC may represent a target for the development of inhibitors for preventing H. influenzae disease.

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Year:  2003        PMID： 12933892      PMCID： PMC187334          DOI： 10.1128/IAI.71.9.5398-5401.2003

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  21 in total

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Authors:  R E Rose
Journal:  Nucleic Acids Res       Date:  1988-01-11       Impact factor: 16.971

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Authors:  P R Martin; R J Shea; M H Mulks
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3.  Signature Tagged Mutagenesis of Haemophilus influenzae identifies genes required for in vivo survival.

Authors:  M A Herbert; S Hayes; M E Deadman; C M Tang; D W Hood; E R Moxon
Journal:  Microb Pathog       Date:  2002-11       Impact factor: 3.738

4.  Haemin and nicotinamide adenine dinucleotide requirements of Haemophilus influenzae and Haemophilus parainfluenzae.

Authors:  N M Evans; D D Smith; A J Wicken
Journal:  J Med Microbiol       Date:  1974-08       Impact factor: 2.472

5.  Defined nongrowth media for stage II development of competence in Haemophilus influenzae.

Authors:  R M Herriott; E M Meyer; M Vogt
Journal:  J Bacteriol       Date:  1970-02       Impact factor: 3.490

6.  NadN and e (P4) are essential for utilization of NAD and nicotinamide mononucleotide but not nicotinamide riboside in Haemophilus influenzae.

Authors:  G Kemmer; T J Reilly; J Schmidt-Brauns; G W Zlotnik; B A Green; M J Fiske; M Herbert; A Kraiss; S Schlör; A Smith; J Reidl
Journal:  J Bacteriol       Date:  2001-07       Impact factor: 3.490

7.  Characterization of Haemophilus influenzae nucleotide pyrophosphatase. An enzyme of critical importance for growth of the organism.

Authors:  D W Kahn; B M Anderson
Journal:  J Biol Chem       Date:  1986-05-05       Impact factor: 5.157

8.  Porin OmpP2 of Haemophilus influenzae shows specificity for nicotinamide-derived nucleotide substrates.

Authors:  Christian Andersen; Elke Maier; Gabrielle Kemmer; Julia Blass; Anna-Karina Hilpert; Roland Benz; Joachim Reidl
Journal:  J Biol Chem       Date:  2003-04-14       Impact factor: 5.157

9.  Crystal structure of Haemophilus influenzae NadR protein. A bifunctional enzyme endowed with NMN adenyltransferase and ribosylnicotinimide kinase activities.

Authors:  S Kumar Singh; Oleg V Kurnasov; Baozhi Chen; Howard Robinson; Nick V Grishin; Andrei L Osterman; Hong Zhang
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10.  Production of Haemophilus influenzae b meningitis in infant rats by intraperitoneal inoculation.

Authors:  A L Smith; D H Smith; D R Averill; J Marino; E R Moxon
Journal:  Infect Immun       Date:  1973-08       Impact factor: 3.441
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Journal:  J Bacteriol       Date:  2006-10       Impact factor: 3.490

4.  Functional mining of transporters using synthetic selections.

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5.  Crystal structure of the vitamin B3 transporter PnuC, a full-length SWEET homolog.

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Review 6.  NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus.

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7.  PnuC and the utilization of the nicotinamide riboside analog 3-aminopyridine in Haemophilus influenzae.

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Review 8.  The CD38 glycohydrolase and the NAD sink: implications for pathological conditions.

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10.  Evolution of the oligopeptide transporter family.

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