Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Molecular phylogeny within type I cytokines and their cognate receptors.

Literature DB >> 12932349

Molecular phylogeny within type I cytokines and their cognate receptors.

Jean-Louis Boulay¹, John J O'Shea, William E Paul.

Abstract

Type I helical cytokines are ligands for receptors structurally related by a common sequence signature. Here we analyze the 27 ligands and 34 human type I cytokine receptor encoded by the human genome. We compare these to ligands and receptors found in mouse and insects. We describe their structural relatedness to one another and discuss the evolution of these gene families.

Entities: Species

Mesh：

Substances：

Year: 2003 PMID： 12932349 DOI： 10.1016/s1074-7613(03)00211-5

Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745

Keyword Cloud
Cited

79 in total

Review 1. Targeting the Jak/STAT pathway for immunosuppression.

Authors: J J O'shea
Journal: Ann Rheum Dis Date: 2004-11 Impact factor: 19.103

Review 2. The executioners sing a new song: killer caspases activate microglia.

Authors: J L Venero; M A Burguillos; P Brundin; B Joseph
Journal: Cell Death Differ Date: 2011-08-12 Impact factor: 15.828

3. Identification of Drosophila genes modulating Janus kinase/signal transducer and activator of transcription signal transduction.

Authors: Tina Mukherjee; Ulrich Schäfer; Martin P Zeidler
Journal: Genetics Date: 2005-12-30 Impact factor: 4.562

Review 4. Therapeutic targeting of Janus kinases.

Authors: Marko Pesu; Arian Laurence; Nandini Kishore; Samuel H Zwillich; Gary Chan; John J O'Shea
Journal: Immunol Rev Date: 2008-06 Impact factor: 12.988

5. A conserved sugar bridge connected to the WSXWS motif has an important role for transport of IL-21R to the plasma membrane.

Authors: P Siupka; O T Hamming; L Kang; H H Gad; R Hartmann
Journal: Genes Immun Date: 2015-06-04 Impact factor: 2.676

Molecular phylogeny within type I cytokines and their cognate receptors.

Review 1. Targeting the Jak/STAT pathway for immunosuppression.

Review 2. The executioners sing a new song: killer caspases activate microglia.

3. Identification of Drosophila genes modulating Janus kinase/signal transducer and activator of transcription signal transduction.

Review 4. Therapeutic targeting of Janus kinases.

5. A conserved sugar bridge connected to the WSXWS motif has an important role for transport of IL-21R to the plasma membrane.

Review 6. Minireview: prolactin regulation of adult stem cells.

Review 7. Neuromodulation by the immune system: a focus on cytokines.

8. Nuclear transit of the intracellular domain of the interferon receptor subunit IFNaR2 requires Stat2 and Irf9.

9. A short receptor downregulates JAK/STAT signalling to control the Drosophila cellular immune response.

Review 10. Organogenesis and tumorigenesis: insight from the JAK/STAT pathway in the Drosophila eye.