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Literature DB >> 12932132

A novel 5-HT receptor ligand and related cytotoxic compounds from an acid mine waste extremophile.

Andrea A Stierle¹, Donald B Stierle, Eric Goldstein, Keith Parker, Tim Bugni, Chad Baarson, Julie Gress, Danielle Blake.

Abstract

Berkeley Pit Lake in Butte, Montana, is an acid mine waste reservoir rich in toxic metals. A Pithomycessp. isolated from the Pit Lake yielded three tyrosine derivatives (1-3), one of which acts as a 5-HT((2a)) receptor ligand. This type of activity has been associated with migraine preventative and antihypertensive drugs. The isolation and characterization of compounds 1-3 and three sesquiterpenes (5-7) that have been isolated previously from higher plants are reported here.

Entities: Chemical Disease Species

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Year: 2003 PMID： 12932132 DOI： 10.1021/np030044w

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

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Cited

10 in total

1. Caspase-1 inhibitors from an extremophilic fungus that target specific leukemia cell lines.

Authors: Andrea A Stierle; Donald B Stierle; Teri Girtsman
Journal: J Nat Prod Date: 2012-02-01 Impact factor: 4.050

2. Caspase-1 and -3 inhibiting drimane sesquiterpenoids from the extremophilic fungus Penicillium solitum.

Authors: Donald B Stierle; Andrea A Stierle; Teri Girtsman; Kyle McIntyre; Jesse Nichols
Journal: J Nat Prod Date: 2012-01-25 Impact factor: 4.050

Review 3. Culturability and secondary metabolite diversity of extreme microbes: expanding contribution of deep sea and deep-sea vent microbes to natural product discovery.

Authors: Robin K Pettit
Journal: Mar Biotechnol (NY) Date: 2010-05-01 Impact factor: 3.619

A novel 5-HT receptor ligand and related cytotoxic compounds from an acid mine waste extremophile.

1. Caspase-1 inhibitors from an extremophilic fungus that target specific leukemia cell lines.

2. Caspase-1 and -3 inhibiting drimane sesquiterpenoids from the extremophilic fungus Penicillium solitum.

Review 3. Culturability and secondary metabolite diversity of extreme microbes: expanding contribution of deep sea and deep-sea vent microbes to natural product discovery.

4. Bioactive secondary metabolites from acid mine waste extremophiles.

5. Stachylines A-D from the sponge-derived fungus Stachylidium sp.

6. The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium.

7. Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri.

Review 8. Germacrene A-A Central Intermediate in Sesquiterpene Biosynthesis.

9. Chemical Constituents With Antiproliferative Activity From Pogostemon cablin (Blanco) Benth.

Review 10. Hedycaryol - Central Intermediates in Sesquiterpene Biosynthesis, Part II.