Literature DB >> 12932009

Synthesis and biological evaluation of cytostatin analogues.

Laurent Bialy1, Herbert Waldmann.   

Abstract

Analogues of the serine/threonine phosphatase 2A inhibitor cytostatin were synthesized and evaluated as inhibitors of various phosphatases in order to establish a basic structure-activity relationship (SAR) of the natural product.

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Year:  2003        PMID： 12932009

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition.

Authors:  Brian G Lawhorn; Sobhana B Boga; Scott E Wolkenberg; David A Colby; Carla-Maria Gauss; Mark R Swingle; Lauren Amable; Richard E Honkanen; Dale L Boger
Journal:  J Am Chem Soc       Date:  2006-12-27       Impact factor: 15.419

Review 2.  Synthetic Strategies Employed for the Construction of Fostriecin and Related Natural Products.

Authors:  Barry M Trost; Joshua D Knopf; Cheyenne S Brindle
Journal:  Chem Rev       Date:  2016-12-08       Impact factor: 60.622

3.  Anti-inflammatory natural product goniothalamin reduces colitis-associated and sporadic colorectal tumorigenesis.

Authors:  Débora Barbosa Vendramini-Costa; Ralph Francescone; David Posocco; Vivianty Hou; Oxana Dmitrieva; Harvey Hensley; João Ernesto de Carvalho; Ronaldo Aloise Pilli; Sergei I Grivennikov
Journal:  Carcinogenesis       Date:  2016-10-24       Impact factor: 4.944

4.  An efficient, modular approach for the synthesis of (+)-strictifolione and a related natural product.

Authors:  Susanthi Jayasinghe; Phanindra K M Venukadasula; Paul R Hanson
Journal:  Org Lett       Date:  2013-12-02       Impact factor: 6.005
  4 in total

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