OBJECTIVE: To investigate if there are relevant differences in clinical, microbiological and outcome characteristics of community-acquired febrile urinary tract infection (UTI) between diabetic and nondiabetic patients. DESIGN: A prospectively matched case-control study. SETTING: An 800-bed tertiary care university-affiliated hospital. SUBJECTS: A total of 108 patients (54 diabetic and 54 nondiabetic patients matched by age and gender) admitted between January 1996 and September 1999 with febrile UTI. METHODS: Clinical, analytical, microbiological and outcome variables were analysed by means of McNemar test (categorical) or Wilcoxon matched pairs signed rank test (continuous). RESULTS: Mean age (SD) in both groups was 67.9 (14.4) years. In comparison with controls, diabetic patients were more likely to have fever without localizing symptoms (27% vs. 9%, P </= 0.0001), diminished consciousness level at admission (25% vs. 10%, P = 0.03), aetiological microorganism different from Escherichia coli (17% vs. 0, P = 0.0004), and quinolone-resistant bacteria (17% vs. 3.7%, P = 0.07). Duration of fever after the onset of treatment was 1.75 (1) days in diabetics and 1.5 (1.1) days in nondiabetics (P = 0.17). However, diabetic patients had a longer hospitalization [5.2 (3.3) days] than nondiabetics [3.9 (2.6) days, P = 0.006]. CONCLUSIONS: In diabetic patients, febrile UTIs have clinical and microbiological peculiarities that may have diagnostic and therapeutic implications.
OBJECTIVE: To investigate if there are relevant differences in clinical, microbiological and outcome characteristics of community-acquired febrile urinary tract infection (UTI) between diabetic and nondiabeticpatients. DESIGN: A prospectively matched case-control study. SETTING: An 800-bed tertiary care university-affiliated hospital. SUBJECTS: A total of 108 patients (54 diabetic and 54 nondiabeticpatients matched by age and gender) admitted between January 1996 and September 1999 with febrile UTI. METHODS: Clinical, analytical, microbiological and outcome variables were analysed by means of McNemar test (categorical) or Wilcoxon matched pairs signed rank test (continuous). RESULTS: Mean age (SD) in both groups was 67.9 (14.4) years. In comparison with controls, diabeticpatients were more likely to have fever without localizing symptoms (27% vs. 9%, P </= 0.0001), diminished consciousness level at admission (25% vs. 10%, P = 0.03), aetiological microorganism different from Escherichia coli (17% vs. 0, P = 0.0004), and quinolone-resistant bacteria (17% vs. 3.7%, P = 0.07). Duration of fever after the onset of treatment was 1.75 (1) days in diabetics and 1.5 (1.1) days in nondiabetics (P = 0.17). However, diabeticpatients had a longer hospitalization [5.2 (3.3) days] than nondiabetics [3.9 (2.6) days, P = 0.006]. CONCLUSIONS: In diabeticpatients, febrile UTIs have clinical and microbiological peculiarities that may have diagnostic and therapeutic implications.
Authors: Willize E van der Starre; Hanneke Borgdorff; Albert M Vollaard; Nathalie M Delfos; Jan W van 't Wout; Ida C Spelt; Jeanet W Blom; Eliane M S Leyten; Ted Koster; Hans C Ablij; Jaap T van Dissel; Cees van Nieuwkoop Journal: Diabetes Care Date: 2013-12 Impact factor: 19.112