Literature DB >> 12925683

The enigma of sepsis.

Niels C Riedemann1, Ren-Feng Guo, Peter A Ward.   

Abstract

Sepsis remains a serious cause of morbidity and mortality, and the pathophysiology of the disease is not clear. The definition of the clinical manifestations of sepsis is ever evolving. This review discusses the search for effective therapeutic interventions, hurdles in translational sepsis research, and new therapies in development in current clinical trials.

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Year:  2003        PMID： 12925683      PMCID： PMC171398          DOI： 10.1172/JCI19523

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  75 in total

1.  Intensive insulin therapy in critically ill patients.

Authors:  G van den Berghe; P Wouters; F Weekers; C Verwaest; F Bruyninckx; M Schetz; D Vlasselaers; P Ferdinande; P Lauwers; R Bouillon
Journal:  N Engl J Med       Date:  2001-11-08       Impact factor: 91.245

2.  Early goal-directed therapy in the treatment of severe sepsis and septic shock.

Authors:  E Rivers; B Nguyen; S Havstad; J Ressler; A Muzzin; B Knoblich; E Peterson; M Tomlanovich
Journal:  N Engl J Med       Date:  2001-11-08       Impact factor: 91.245

3.  Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care.

Authors:  D C Angus; W T Linde-Zwirble; J Lidicker; G Clermont; J Carcillo; M R Pinsky
Journal:  Crit Care Med       Date:  2001-07       Impact factor: 7.598

Review 4.  Anti-tumor necrosis factor therapy in sepsis: update on clinical trials and lessons learned.

Authors:  K Reinhart; W Karzai
Journal:  Crit Care Med       Date:  2001-07       Impact factor: 7.598

5.  Efficacy and safety of recombinant human activated protein C for severe sepsis.

Authors:  G R Bernard; J L Vincent; P F Laterre; S P LaRosa; J F Dhainaut; A Lopez-Rodriguez; J S Steingrub; G E Garber; J D Helterbrand; E W Ely; C J Fisher
Journal:  N Engl J Med       Date:  2001-03-08       Impact factor: 91.245

6.  Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte.

Authors:  R S Hotchkiss; K C Chang; P E Swanson; K W Tinsley; J J Hui; P Klender; S Xanthoudakis; S Roy; C Black; E Grimm; R Aspiotis; Y Han; D W Nicholson; I E Karl
Journal:  Nat Immunol       Date:  2000-12       Impact factor: 25.606

7.  Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial.

Authors:  B L Warren; A Eid; P Singer; S S Pillay; P Carl; I Novak; P Chalupa; A Atherstone; I Pénzes; A Kübler; S Knaub; H O Keinecke; H Heinrichs; F Schindel; M Juers; R C Bone; S M Opal
Journal:  JAMA       Date:  2001-10-17       Impact factor: 56.272

Review 8.  Apoptosis in sepsis: a new target for therapeutic exploration.

Authors:  C Oberholzer; A Oberholzer; M Clare-Salzler; L L Moldawer
Journal:  FASEB J       Date:  2001-04       Impact factor: 5.191

9.  Plasma levels of macrophage migration inhibitory factor are elevated in patients with severe sepsis.

Authors:  L E Lehmann; U Novender; S Schroeder; T Pietsch; T von Spiegel; C Putensen; A Hoeft; F Stüber
Journal:  Intensive Care Med       Date:  2001-08       Impact factor: 17.440

10.  Macrophage migration inhibitory factor is a critical mediator of systemic inflammatory response syndrome.

Authors:  S Gando; J Nishihira; S Kobayashi; Y Morimoto; S Nanzaki; O Kemmotsu
Journal:  Intensive Care Med       Date:  2001-07       Impact factor: 17.440
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  209 in total

1.  Caveolin-1 protects against sepsis by modulating inflammatory response, alleviating bacterial burden, and suppressing thymocyte apoptosis.

Authors:  Hong Feng; Ling Guo; Zhiqing Song; Haiqing Gao; Dan Wang; Weisi Fu; Jingyan Han; Zhenyu Li; Bin Huang; Xiang-An Li
Journal:  J Biol Chem       Date:  2010-06-09       Impact factor: 5.157

2.  Adenosine A2A receptor inactivation increases survival in polymicrobial sepsis.

Authors:  Zoltán H Németh; Balázs Csóka; Jeanette Wilmanski; Dazhong Xu; Qi Lu; Catherine Ledent; Edwin A Deitch; Pál Pacher; Zoltán Spolarics; György Haskó
Journal:  J Immunol       Date:  2006-05-01       Impact factor: 5.422

3.  Cathelicidin peptide LL-37 modulates TREM-1 expression and inflammatory responses to microbial compounds.

Authors:  Gimano D Amatngalim; Anastasia Nijnik; Pieter S Hiemstra; Robert E W Hancock
Journal:  Inflammation       Date:  2011-10       Impact factor: 4.092

Review 4.  Gene-specific epigenetic regulation in serious infections with systemic inflammation.

Authors:  Charles E McCall; Barbara Yoza; Tiefu Liu; Mohamed El Gazzar
Journal:  J Innate Immun       Date:  2010-04-27       Impact factor: 7.349

5.  High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy.

Authors:  Yoko Oyama; Teruto Hashiguchi; Noboru Taniguchi; Salunya Tancharoen; Tomonori Uchimura; Kamal K Biswas; Ko-Ichi Kawahara; Takao Nitanda; Yoshihisa Umekita; Martin Lotz; Ikuro Maruyama
Journal:  Lab Invest       Date:  2010-03-15       Impact factor: 5.662

Review 6.  Advances in the management of sepsis and the understanding of key immunologic defects.

Authors:  Lee P Skrupky; Paul W Kerby; Richard S Hotchkiss
Journal:  Anesthesiology       Date:  2011-12       Impact factor: 7.892

7.  Chronic kidney disease worsens sepsis and sepsis-induced acute kidney injury by releasing High Mobility Group Box Protein-1.

Authors:  Asada Leelahavanichkul; Yuning Huang; Xuzhen Hu; Hua Zhou; Takayuki Tsuji; Richard Chen; Jeffrey B Kopp; Jürgen Schnermann; Peter S T Yuen; Robert A Star
Journal:  Kidney Int       Date:  2011-08-10       Impact factor: 10.612

8.  Factor XI-deficient mice display reduced inflammation, coagulopathy, and bacterial growth during listeriosis.

Authors:  Deyan Luo; Frank M Szaba; Lawrence W Kummer; Lawrence L Johnson; Erik I Tucker; Andras Gruber; David Gailani; Stephen T Smiley
Journal:  Infect Immun       Date:  2011-10-17       Impact factor: 3.441

Review 9.  Tubular cross talk in acute kidney injury: a story of sense and sensibility.

Authors:  Tarek M El-Achkar; Pierre C Dagher
Journal:  Am J Physiol Renal Physiol       Date:  2015-04-15

10.  Caging a Beast in the Inflammation Arena: Use of Chinese Medicinal Herbs to Inhibit a Late Mediator of Lethal Sepsis, HMGB1.

Authors:  Shu Zhu; Wei Li; Jianhua Li; Andrew E Sama; Haichao Wang
Journal:  Int J Clin Exp Med       Date:  2008-01-20
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