OBJECTIVE: To investigate the role of macrophage migration inhibitory factor (MIF) as a marker of severity of systemic inflammation in patients with severe sepsis and critically ill postsurgical patients. DESIGN: Prospective observational study in consecutive patients with severe sepsis, critically ill nonseptic postsurgical patients, and healthy blood donors. SETTING: A surgical intensive care unit of a university hospital. PATIENTS AND PARTICIPANTS: 19 patients with severe sepsis, 18 critically ill nonseptic postsurgical patients, and 10 healthy blood donors. MEASUREMENTS AND RESULTS: MIF plasma levels of patients and participants were measured. Interleukin 6 plasma levels were monitored as a control marker of inflammation. The median MIF plasma level was four to five times higher in patients with severe sepsis (2.70 ng/ml, range 0.31-19.59) and in critically ill nonseptic postsurgical patients (2.43 ng/ml, range 0.49-4.31) than in healthy blood donors (0.56 ng/ml, range 0.16-1.68). MIF plasma levels did not differ between the patient groups. CONCLUSIONS: MIF serves as a general marker for systemic inflammation in septic and nonseptic acute critical illness, but MIF does not discriminate for severity or differentiate between infectious and noninfectious origins of an acute critical illness.
OBJECTIVE: To investigate the role of macrophage migration inhibitory factor (MIF) as a marker of severity of systemic inflammation in patients with severe sepsis and critically ill postsurgical patients. DESIGN: Prospective observational study in consecutive patients with severe sepsis, critically ill nonseptic postsurgical patients, and healthy blood donors. SETTING: A surgical intensive care unit of a university hospital. PATIENTS AND PARTICIPANTS: 19 patients with severe sepsis, 18 critically ill nonseptic postsurgical patients, and 10 healthy blood donors. MEASUREMENTS AND RESULTS:MIF plasma levels of patients and participants were measured. Interleukin 6 plasma levels were monitored as a control marker of inflammation. The median MIF plasma level was four to five times higher in patients with severe sepsis (2.70 ng/ml, range 0.31-19.59) and in critically ill nonseptic postsurgical patients (2.43 ng/ml, range 0.49-4.31) than in healthy blood donors (0.56 ng/ml, range 0.16-1.68). MIF plasma levels did not differ between the patient groups. CONCLUSIONS:MIF serves as a general marker for systemic inflammation in septic and nonseptic acute critical illness, but MIF does not discriminate for severity or differentiate between infectious and noninfectious origins of an acute critical illness.
Authors: Melanie Merk; Swen Zierow; Lin Leng; Rituparna Das; Xin Du; Wibke Schulte; Juan Fan; Hongqi Lue; Yibang Chen; Huabao Xiong; Frederic Chagnon; Jürgen Bernhagen; Elias Lolis; Gil Mor; Olivier Lesur; Richard Bucala Journal: Proc Natl Acad Sci U S A Date: 2011-08-04 Impact factor: 11.205
Authors: Susannah K Leaver; Niall S MacCallum; Vasisht Pingle; Matthew B Hacking; Gregory J Quinlan; Timothy W Evans; Anne Burke-Gaffney Journal: Intensive Care Med Date: 2009-09-15 Impact factor: 17.440
Authors: Lutz E Lehmann; Malte Book; Wolfgang Hartmann; Stefan U Weber; Jens-Christian Schewe; Sven Klaschik; Andreas Hoeft; Frank Stüber Journal: J Transl Med Date: 2009-11-26 Impact factor: 5.531
Authors: W Joost Wiersinga; Thierry Calandra; Liesbeth M Kager; Gerritje J W van der Windt; Thierry Roger; Didier le Roy; Sandrine Florquin; Sharon J Peacock; Fred C G J Sweep; Tom van der Poll Journal: PLoS Negl Trop Dis Date: 2010-02-16