Combining dependent tests for linkage or association across multiple phenotypic traits.

A robust statistical method to detect linkage or association between a genetic marker and a set of distinct phenotypic traits is to combine univariate trait-specific test statistics for a more powerful overall test. This procedure does not need complex modeling assumptions, can easily handle the problem with partially missing trait values, and is applicable to the case with a mixture of qualitative and quantitative traits. In this note, we propose a simple test procedure along this line, and show its advantages over the standard combination tests for linkage or association in the literature through a data set from Genetic Analysis Workshop 12 (GAW12) and an extensive simulation study.