OBJECTIVE: To determine whether nitric oxide production levels differ in patients with deficit and non-deficit forms of schizophrenia. METHODS: We investigated plasma nitrate levels, an index of in vivo nitric oxide production, in patients with deficit syndrome (n = 11) and non-deficit syndrome (n = 14) and healthy controls (n = 12) with a combination of high-performance liquid chromatography and the Griess reaction. RESULTS: There was no difference found in mean plasma nitrite levels, but plasma nitrate levels of patients with deficit syndrome were significantly lower than those with non-deficit syndrome (28.0 [SEM 2.5] micromol/L v. 44.2 [SEM 5.5] micromol/L, p < 0.05). CONCLUSIONS: A decline in nitric oxide production may be involved in primary negative symptoms in schizophrenia.
OBJECTIVE: To determine whether nitric oxide production levels differ in patients with deficit and non-deficit forms of schizophrenia. METHODS: We investigated plasma nitrate levels, an index of in vivo nitric oxide production, in patients with deficit syndrome (n = 11) and non-deficit syndrome (n = 14) and healthy controls (n = 12) with a combination of high-performance liquid chromatography and the Griess reaction. RESULTS: There was no difference found in mean plasma nitrite levels, but plasma nitrate levels of patients with deficit syndrome were significantly lower than those with non-deficit syndrome (28.0 [SEM 2.5] micromol/L v. 44.2 [SEM 5.5] micromol/L, p < 0.05). CONCLUSIONS: A decline in nitric oxide production may be involved in primary negative symptoms in schizophrenia.
Authors: Mariana C Diana; Fernanda F Peres; Veronica Justi; Rodrigo A Bressan; Acioly L T Lacerda; José Alexandre Crippa; Jaime E C Hallak; Vanesssa Costhek Abilio Journal: CNS Neurosci Ther Date: 2018-04-14 Impact factor: 5.243
Authors: Mary-Anne B MacKay; John W Paylor; James T F Wong; Ian R Winship; Glen B Baker; Serdar M Dursun Journal: Front Psychiatry Date: 2018-10-30 Impact factor: 4.157