Ji-Young Park1, Yeon-Lim Suh, Joungho Han. 1. Department of Diagnostic Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Abstract
OBJECTIVE: To evaluate the diagnostic usefulness of intraoperative cytologic preparations from dysembryoplastic neuroepithelial tumor (DNTs). STUDY DESIGN: We reviewed squash preparations from 17 DNTs and compared them to those from 12 oligodendrogliomas and the histology of frozen sections from the same tumors. RESULTS: The floating neurons and extracellular mucin typical of DNT were more easily demonstrated in cytologic preparations than in frozen sections. Cytologically, oligodendroglialike cells of DNT were distinguished from oligodendrogliomas by larger nuclei with frequent nuclear indentation and multiple, small nucleoli, while oligodendrogliomas consistently showed nuclear roundness of tumor cells with 1 or 2 occasional nuclei. The presence of eosinophilic granular bodies in the background was an ancillary sign of DNT. CONCLUSION: The cytologic features of squash preparations of DNT are fairly characteristic and reliable for the correct intraoperative diagnosis of DNT, helping to determine the appropriate neurosurgical procedure.
OBJECTIVE: To evaluate the diagnostic usefulness of intraoperative cytologic preparations from dysembryoplastic neuroepithelial tumor (DNTs). STUDY DESIGN: We reviewed squash preparations from 17 DNTs and compared them to those from 12 oligodendrogliomas and the histology of frozen sections from the same tumors. RESULTS: The floating neurons and extracellular mucin typical of DNT were more easily demonstrated in cytologic preparations than in frozen sections. Cytologically, oligodendroglialike cells of DNT were distinguished from oligodendrogliomas by larger nuclei with frequent nuclear indentation and multiple, small nucleoli, while oligodendrogliomas consistently showed nuclear roundness of tumor cells with 1 or 2 occasional nuclei. The presence of eosinophilic granular bodies in the background was an ancillary sign of DNT. CONCLUSION: The cytologic features of squash preparations of DNT are fairly characteristic and reliable for the correct intraoperative diagnosis of DNT, helping to determine the appropriate neurosurgical procedure.
Authors: Guillaume Bergthold; Pratiti Bandopadhayay; Wenya Linda Bi; Lori Ramkissoon; Charles Stiles; Rosalind A Segal; Rameen Beroukhim; Keith L Ligon; Jacques Grill; Mark W Kieran Journal: Biochim Biophys Acta Date: 2014-02-28
Authors: Oluwole Fadare; M Rajan Mariappan; Denise Hileeto; Arthur W Zieske; Jung H Kim; Idris Tolgay Ocal Journal: Cytojournal Date: 2005-01-11 Impact factor: 2.091