| Literature DB >> 12919029 |
Scott S Harried1, Christopher P Lee, Ge Yang, Tony I H Lee, David C Myles.
Abstract
The total synthesis of the potent microtubule-stabilizing, antimitotic agent (+)-discodermolide is described. The convergent synthetic strategy takes advantage of the diastereoselective alkylation of a ketone enolate to establish the key C15-C16 bond. The synthesis is amenable to preparation of gram-scale quantities of (+)-discodermolide and analogues.Entities:
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Year: 2003 PMID： 12919029 DOI： 10.1021/jo034521r
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354